Scavenging Activity, Anti-Inflammatory and Diabetes Related Enzyme Inhibition Properties of Leaves Extract from some Varieties of Phoenyx dactylifera l.

Eddine, Laouini Salah; Segni, Ladjel; Noureddine, Gherraf; Redha, Ouahrani Mohammed; Sonia, Mokni

doi:10.18052/www.scipress.com/ILCPA.14.125

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Scavenging Activity, Anti-Inflammatory and Diabetes Related Enzyme Inhibition Properties of Leaves Extract from some Varieties of Phoenyx dactylifera l.

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Abstract:

In this study we investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: “Ghars”, “Deglet Nour” and “Hamraya”. The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of α-amylase enzymes. The total phenolic content measured by Folin-Ciocalteu method was as well conducted. The raw leaves extracts of the selected varieties was found to contain a high content of total phenolic content (342.45 mg GAE/gDW for GE) and therefore exhibited a higher antioxidant activity and inhibitory effect of radicals scavenging activity against DPPH and superoxide anion (IC₅₀ = 7.44 μg/mL and 39.11 μg/mL respectively). The three varieties exhibited significant inhibition nitric oxide using In Vitro assay (IC50 = 240.28 μg/mL for GE). The extracts also displayed high inhibition actions against α-amylase enzymes. The results suggest that the leaves of the three selected varieties of Phoenyx dactylifera can be considered as a good source of natural antioxidant and anti-inflammation drugs as well as potent antidiabetic medicine.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 14)

Pages:

125-135

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.14.125

Citation:

L. S. Eddine et al., "Scavenging Activity, Anti-Inflammatory and Diabetes Related Enzyme Inhibition Properties of Leaves Extract from some Varieties of Phoenyx dactylifera l.", International Letters of Chemistry, Physics and Astronomy, Vol. 14, pp. 125-135, 2013

Online since:

May 2013

Authors:

Laouini Salah Eddine, Ladjel Segni, Gherraf Noureddine, Ouahrani Mohammed Redha, Mokni Sonia

Keywords:

Antidiabetic, Anti-Inflammatory, Leaves Extract, Phenolic Content, Phoenyx dactylifera L, Scavenger Activity

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Open Access

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Creative Commons Attribution 4.0 International License

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