Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
Volume 14


Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 14 > Chemical Constituents from Fadogia homblei De Wild...
< Back to Volume

Chemical Constituents from Fadogia homblei De Wild (Rubiaceae)

Full Text PDF


The total of fourteen known compounds was isolated from the fruits, leaf and stem of Fadogia homblei De Wild. (Rubiaceae) and identified as: a coumarin, 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one (scopoletin) 1, two flavones; 3′,4′,5,7-tetrahydroxyflavone (luteolin) 2 and quercetin-3-O-β-D-galactoside 3, four lupane triterpenoids; lupeol 4, betulinic acid 5, 3β-dodecanoyllup-20(29)-en-28-al 6, lup-20(29)-en-3β-ylhexadecanoate 7, and two steroids; sitosterol 8, stigmasterol 9, a lignan 4,4′-dihydroxy-3,3′-dimethoxy-7,9′:7′,9-diepoxylignan ((-)-pinoresinol) 10, a phaeophytin A 11, an uracil 12, an oleanolic acid 13, and an ursolic acid 14. To our best knowledge, this is the first report for isolation of these compounds from this species. This finding is nevertheless significant as it is the first report of uracil from a plant source other than from various species of ferns.


International Letters of Chemistry, Physics and Astronomy (Volume 14)
A. M.A. Mohammed et al., "Chemical Constituents from Fadogia homblei De Wild (Rubiaceae)", International Letters of Chemistry, Physics and Astronomy, Vol. 14, pp. 116-124, 2013
Online since:
Sep 2013

B. van Wyk, F. van Heerden, B. van Oudtshoorn, Poisonous Plants of Southern Africa, Briza publications, Pretoria, South Africa (2005) p.110.

T. S. Kellerman, J. A. W. Coetzer, T. W. Naude, Plant Poisonings and Mycotoxicoses of Livestock in Southern Africa, Oxford University Press, Cape Town (1988) p.115.

L. R. Hurter, T. W. Naude, T. F. Adelaar, J. D. Smit, L. E. Codd, Onderstepoort J. Vet. Res. 39 (1972) 71-82.

N. Fourie, R. A. Schultz, L. Prozesky, T. S. Kellerman, L. Labuschagne, Onderstepoort J. Vet. Res. 56 (1989) 73.

L. Prozesky, S. S. Bastianello, N. Fourie, R. A. Schultz, Onderstepoort J. Vet. Res. 72 (2005) 219.

M. L. Bode, P. J. Gates, S. Y. Gebretnsae, R. Vleggaar, Tetrahedron 66 (2010) (2026).

N. Fourie, G. L. Eramus, R. A. Schultz, L. Prozesky, Onderstepoort J. Vet. Res 62 (1995) 77.

R. Anero, A. Diaz-Lanza, E. Ollivier, B. Baghdikian, G. Balansard, M. Bernabe, Phytochemistry 69 (2008) 805.

S. Sanon, E. Ollivier, N. Azas, V. Mahiou, M. Gasquet, C. T. Ouattara, I. Nebie, A. S. Traore, F. Esposito, G. Balansard, P. Timon-David, F. Fumoux, J. Ethnopharmacol. 86 (2003) 143.

M. T. Yakubu, M. A. Akanji, A. T. J. Oladiji , J. Ethnopharmacol. 115 (2008) 288.

M. C. Carpinella, C. G. Ferrayoli, S. M. Palacios, J. Agric. Food Chem. 53 (2005) 2922-2927.

C. H. Jarboe, K. A. Zirvi, J. A. Nicholson, C. M. Schmidt, J. Amer. Chem. Soc. 10 (1967) 488-489.

F. Abas, N. H. Lajis, K. Shaari, D. A. Israf, J. Stanslas, U. K. Yusuf, S. M. Raof, J. Nat. Prod 68 (2005) 1090-1093.

J. S. Kim, J. C. Kim, S. H. Shim, E. J. Lee, W. Y. Jin, K. Bae, K. H. Son, H. P. Kim, S. P. Kang, H. W. Chang, Arch. Pharmacal Res. 29 (2006) 619-623.

M. M. Badawi, A. A. Seida, A. D. Kinghorn, G. A. Cordell, N. R. Farnsworth, J. Nat. Prod. 44 (1981) 331-334.

X-Z. Chen, H-F. Wu, S-M. Lu, B-G. Li, D-G. Fang, G-L. Zhang, Helv. Chim. Acta 91 (2008) 1072.

K. R. Markham, B. Ternai, R. Stanley, H. Geiger, T. J. Mabry, Tetrahedron 34 (1978) 1389-1397.

P. Dzubak, M. Hajduch, D. Vydra, A. Hustova, M. Kvasnica, D. Biederann, L. Markova, M. Urban, Sarek, J., Nat. Prod. Reports 23 (2006) 394-411.

E. M. Mwangi, Ph.D. Thesis, University of KwaZulu-Natal, Durban (2007).

J. Fotie, D. S. Bohle, M. L. Leimanis, E. Georges, G. Rukunga, A. E. Nkengfack, J. Nat. Prod. 69 (2006) 62-67.

R. H. Cichewicz, S. A. Kouzi, Medicinal Res. Rev. 24 (2004) 90-114.

S. Deng, A. K. Palu, B. J. West, C. X. Su, B-N. Zhou, J.C. Jensen, J. Nat. Prod. 70 (2007) 859-862.

S. L. Schwikkard, D. A. Mulholland, A. Hutchings., Phytochemistry 49 (1998) 2391.

S.W. Yoo, J. S. Kim, S. S. Kang, K. H. Son, H. W. Chang, H. P. Kim, K. Bae, C-O. Lee, Arch. Pharmacal Res. 25 (2002) 824.

Y. S. Lee, H. S. Lee, K. H. Shin, B-K. Kim, S. Lee, Arch. Pharmacal Res. 27 (2004) 1034-1036.

Y. Kashiwada, H-K. Wang, T. Nagao, S. Kitanaka, I. Yasuda, T. Fujioka, T. Yamagishi, L. H. Cosentino, M. Kozuka, H. Okabe, Y. Ikeshiro, C-Q. Hu, E. Yeh, KH. Lee, J. Nat. Prod. 61 (1998) 1090-1095.

C. G. Caldwell, S. G. Franzblau, E. Suarez, B. N. Timmermann, J. Nat. Prod. 63 (2000) 1611-1614.

M. Makino, T. Motegi, Y. Fujimoto, Phytochemistry 65 (2004) 891-896.

A. T. C. Taketa, S. C. B. Gnoatto, G. Gosmann, V. S. Pires, E. P. Schenkel, D. Guillaume, J. Nat. Prod. 67 (2004) 1697-1700. ( Received 03 May 2013; accepted 07 May 2013 ).

Show More Hide