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Phytochemical Profile and Antifungal Activity of Leaves Methanol Extract from the Psydrax dicoccos (Gaertn) Teys. & Binn. Rubiaceae Family

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Abstract:

The present study was aimed to antifungal activity and phytoconstituents of leaves from the Psydrax dicoccos Gaertn. The antifungal activity of methanol extract from the P. dicoccos against Candida albicans, C. krusei, C. guilliermondii, C. parapsilosis, C. tropicalis, C. glabrata, four dermatophytes viz., Trichophyton rubrum, T. mentagrophytes, Microsporum gypseum and Epidermophyton flocossum. The methanol extract of the leaves were subjected to Fourier transform infrared spectroscopy (FT-IR) and Gas Chromatography-Mass Spectroscopic (GC-MS) analysis. The mean zones of inhibition produced by the tested extract in disc diffusion assays against fungal strains were ranged from 7.3 to 15.5 mm. The MIC values were between 125 and 500 µg/ml while, the MFC values were between 250 and 1000 µg/ml. The highest mean zones of inhibition (15.5±0.6 mm) was observed with methanol extract of P. dicoccos against C. albicans. The GC-MS analysis of P. dicoccos leaves showed the presence of cinnamic acid, 2H-1-Benzopyran-2-one,5,7-dimethoxy,(Z)6,(Z)9-Pentadecadien-1-ol, Benzofuran and n-Hexadecanoic acid as major compounds. Finally it can be concluded that the antifungal activity may be present in cinnamic acid, 2H-1-Benzopyran-2-one, 5, 7-, (Z) 6,(Z)9-Pentadecadien-1-ol, n-Hexadecanoic acid from the methanol extract from the P. dicoccos is highly valuable in medicinal usage and have fewer side effects.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 7)
Pages:
53-61
DOI:
10.18052/www.scipress.com/IJPPE.7.53
Citation:
D. Umaiyambigai et al., "Phytochemical Profile and Antifungal Activity of Leaves Methanol Extract from the Psydrax dicoccos (Gaertn) Teys. & Binn. Rubiaceae Family", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 7, pp. 53-61, 2017
Online since:
Jun 2017
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