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Flavonoids and Diarylheptanoids: Neuroprotective Activities of Phytochemicals

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Plants are often used as sources of lead compounds with phenolic compounds frequently attributed to physiological effects. Flavonoids and diarylheptanoids are important groups of phenolic compounds that impart antioxidant, antitumorgenic, antinflammatory, and neuroprotective effects. These neuroprotective effects can be harnessed to develop treatments for neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. Recent discoveries have characterized new neuroprotective compounds and/or sources and tested treatments on cell lines and model animals to improve treatments for future persons with neurodegenerative disorders.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 6)
K. Parasram "Flavonoids and Diarylheptanoids: Neuroprotective Activities of Phytochemicals", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 6, pp. 82-86, 2017
Online since:
Jan 2017

[1] A. Nakajima et al., Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD), Behav. Brain Res. 289 (2015) 69-77.

[2] S.L. Costa et al., Impact of plant-derived flavonoids on neurodegenerative diseases, Neurotox. Res. (2016) 1-12.

[3] F. Moosavi et al., Modulation of neurotrophic signaling pathways by polyphenols, Drug Des. Develop. and Therapy. 10 (2016) 23.

[4] I. Solanki et al., Flavonoid-based therapies in the early management of neurodegenerative diseases, Advances in Nutrition: An International Review Journal. 6(1) (2015) 64-72.

[5] J. Xu, M.H. Lacoske, E.A. Theodoraki, Neurotrophic natural products: chemistry and biology, Angewandte Chemie Int. Ed. 53(4) (2014) 956-987.

[6] G. Tang et al., A natural diarylheptanoid promotes neuronal differentiation via activating ERK and PI3K-AKT dependent pathways, Neurosci. 303 (2015) 389-401.

[7] C. Rendeiro, J.S. Rhodes, J.P. Spencer, The mechanisms of action of flavonoids in the brain: direct versus indirect effects, Neurochem. Int. 89 (2015) 126-139.

[8] S.L. Xu et al., Flavonoids, derived from traditional Chinese medicines, show roles in the differentiation of neurons: possible targets in developing health food products, Birth Defects Res. Part C: Embryo Today: Rev. 99(4) (2013) 292-299.

[9] Y. Wu et al., Study of neuroprotective function of Ginkgo biloba extract (EGb761) derived‐flavonoid monomers using a three‐dimensional stem cell‐derived neural model, Biotech. Progress. 32(3) (2016) 735-744.

[10] G.A.R. Johnston, Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA, Neurochem. Int. 89 (2015) 120-125.

[11] A.M. Sabogal-Guáqueta et al., The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice, Neuropharmaco. 93 (2015) 134-145.

[12] R. Ren et al., Neuroprotective Effects of a standardized flavonoid extract of safflower against neurotoxin-induced cellular and animal models of Parkinson's disease, Sci. Reports. 6 (2016).

[13] J. Dinić et al., Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes, Fitoterapia. 105 (2015) 169-176.

[14] P. Ferri et al., Enhancement of flavonoid ability to cross the blood–brain barrier of rats by co-administration with α-tocopherol, Food and Func. 6(2) (2015) 394-400.

[15] Information on https: /web. chemdoodle. com/demos/sketcher.

[16] I. Solanki, P. Parihar, M.S. Parihar, Neurodegenerative diseases: From available treatments to prospective herbal therapy, Neurochem. Int. 95 (2016) 100-108.

[17] S.R. Kim, Inhibition of microglial activation and induction of neurotrophic factors by flavonoids: a potential therapeutic strategy against Parkinson's disease, Neural Regen. Res. 10(3) (2015) 363.

[18] M.J. Chung et al., Neuroprotective effects of phytosterols and flavonoids from Cirsium setidens and Aster scaber in human brain neuroblastoma SK-N-SH cells, Life Sci. 148 (2016) 173-182.

DOI: 10.1016/j.lfs.2016.02.035

[19] F. Dajas et al., Quercetin in brain diseases: Potential and limits, Neurochem. Int. 89 (2015) 140-148.

[20] Y. Xu et al., Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats, Brain Res. 1162 (2007) 9-18.

DOI: 10.1016/j.brainres.2007.05.071

[21] Y.M. Tsai et al., Curcumin and its nano-formulation: the kinetics of tissue distribution and blood–brain barrier penetration, Int. J. Pharmaceutics. 416(1) (2011) 331-338.

DOI: 10.1016/j.ijpharm.2011.06.030

[22] S. Dong et al., Curcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity, PLoS One. 7(2) (2012) e31211.

[23] N. Cho et al., Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice, Biosci. Biotech. Biochem. 80(1) (2016) 166-171.

[24] K. Caldwell et al., Dietary flavonoid intake and cognitive performance in older adults with Alzheimer's type dementia, J. of Aging Res. and Clinical Practice. 5(2) (2016) 93-97.

[25] K.C. Santos et al., Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate‐induced cell damage in mice hippocampal slices, J. Pharm. Pharmacology. 68(2) (2016) 282-291.

[26] M.I. Ayuso, J. Montaner, Advanced neuroprotection for brain ischemia: an alternative approach to minimize stroke damage, Expert Opinion on Investig. Drugs. 24(9) (2015) 1137-1142.

[27] C. Echeverry et al., Antioxidant activity, cellular bioavailability, and iron and calcium management of neuroprotective and nonneuroprotective flavones, Neurotox. Res. 27(1) (2015) 31-42.

[28] D.S. Lee et al., Acerogenin A from Acer nikoense maxim prevents oxidative stress-induced neuronal cell death through Nrf2-mediated heme oxygenase-1 expression in mouse hippocampal HT22 cell line, Molecules. 20(7) (2015) 12545-12557.

[29] Q. Hu et al., Identification of flavonoids from Flammulina velutipes and its neuroprotective effect on pheochromocytoma-12 cells, Food Chem. 204 (2016) 274-282.

[30] Y. Lai et al., 6, 8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortune, Fitoterapia. 112 (2016) 237-243.

[31] J. W Jung et al., Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities, Archives of Pharmacal Res. 38(11) (2015) 2066-(2075).

[32] L.P. Köse et al., LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes, Indust. Crops and Prod. 74 (2015) 712-721.

DOI: 10.1016/j.indcrop.2015.05.034

[33] J. Li et al., Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L. ) Pierre, Bioorganic and Med. Chem. Letters. 25(1) (2015) 53-58.

[34] M.E. Pak et al., Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects, J. Ethnopharmacol. 179 (2016) 383-390.

[35] L. Xiang et al., Chemical constituent and antioxidant activity of the husk of Chinese hickory, J. Funct. Foods. 23 (2016) 378-388.

[36] M.S. Ola et al., Neuroprotective effects of rutin in streptozotocin-induced diabetic rat retina, J. Mol. Neurosci. 56(2) (2015) 440-448.

[37] S.D. Wu et al., Ginsenoside-Rd promotes neurite outgrowth of PC12 cells through MAPK/ERK-and PI3K/AKT-dependent pathways, Int. J. Mol. Sci. 17(2) (2016) 177.

[38] J.L. Zhen et al., Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling, Epilepsy and Behavior. 57 (2016) 177-184.

[39] Q. Zhao et al., Echinacoside protects against MPP+-induced neuronal apoptosis via ROS/ATF3/CHOP pathway regulation, Neurosci. Bulletin. 32(4) (2016) 349-362.

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