Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

IJPPE > IJPPE Volume 6 > Changes in Gene Expression Linked to Adverse...
< Back to Volume

Changes in Gene Expression Linked to Adverse Health Effects of Herbicide Atrazine

Full Text PDF


Atrazine is widely-used as an agricultural herbicide and has contaminated some watersupply. Here we review recent studies showing atrazine affects the expression of multiple genes, whichin turn disrupts physiological functions in metabolism, reproduction, immune system, and cell division.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 6)
A. Concilla and H. Liu, "Changes in Gene Expression Linked to Adverse Health Effects of Herbicide Atrazine", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 6, pp. 17-20, 2017
Online since:
January 2017

[1] A. Concilla, H. Liu, Measurement of atrazine concentrations in local water and common foods, SigmaXi 25th Annual Undergraduate Student Research and Creative Accomplishment Conference, (2016).

[2] A. Concilla, H. Liu, Presence of agricultural herbicide atrazine in local water and common foods, Celebrate Gannon, Erie, PA, (2016).

[3] A. Gely-Pernot et al., The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine, BMC Genomics. 16 (2015) 885.

[4] K. Pogrmic et al., Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in Leydig cells, Toxicol Sci. 111 (2009) 189-197.

[5] J.L. Rayner, C. Wood, S.E. Fenton, Exposure parameters necessary for delayed puberty and mammary gland development in Long-Evans rats exposed in utero to atrazine, Toxicol. Appl. Pharmacol. 195 (2004) 23-34.

[6] C. Cantemir et al., p.53 protein expression in peripheral lymphocytes from atrazine chronically intoxicated rats, Toxicol. Lett. 93 (1997) 87-94.


[7] L.E. Thueson et al., In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells, Toxicol. Sci. 143 (2015) 418-429.

[8] K. Ma et al., Neurotoxicity effects of atrazine-induced SH-SY5Y human dopaminergic neuroblastoma cells via microglial activation, Mol. Biosyst. 11 (2015) 2915-2924.

[9] W. Liu et al., Effects of atrazine on the oxidative damage of kidney in Wister rats, Int. J. Clin. Exp. Med. 7 (2014) 3235-3243.

[10] F. Zhao et al., Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response, Int. J. Clin. Exp. Pathol. 7 (2014) 2780-2789.

[11] S. Sagarkar et al., Atrazine exposure causes mitochondrial toxicity in liver and muscle cell lines, Indian J. Pharmacol. 48 (2016) 200-207.


[12] P. Huang et al., Atrazine Triggers DNA Damage Response and Induces DNA Double-Strand Breaks in MCF-10A Cells, Int. J. Mol. Sci. 16 (2015) 14353-14368.


[13] L. Peyre, N. Zucchini-Pascal, R. Rahmani, Atrazine represses S100A4 gene expression and TPA-induced motility in HepG2 cells, Toxicol. in Vitro. 28(2) (2014) 156-163.


[14] L. Albanito et al., Effects of atrazine on estrogen receptor alpha- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts, Environ. Health Perspect. 123 (2015) 493-499.

[15] W. Fan et al., Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans, Environ. Health Perspect. 115 (2007) 720-727.


[16] K. Hu et al., Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling, Int. J. Oncol. 48 (2016) 2166-2174.

Show More Hide
Cited By:

[1] Q. Tian, Y. Zhang, Z. Jia, Q. Zhang, "Synthesis and hard water resistance mechanism of polycarboxylate dispersant for pesticide water dispersible granules", Journal of Dispersion Science and Technology, p. 1, 2019


[2] Q. Tian, Q. Zhang, "Synthesis and performance of sodium salt of MAA/St/SAS copolymer dispersant", IOP Conference Series: Earth and Environmental Science, Vol. 310, p. 042032, 2019