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Preliminary Screening for Anti-Inflammatory, Anti-Nociceptive and Antioxidant Activities of Five New Synthesized Paratoluene Sulphonamide Derivatives of Amino Acids

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Abstract:

The anti-inflammatory, antinociceptive and antioxidant activities of five new synthesized paratoluene sulphonamide derivatives of amino acids were evaluated in this study. The anti-inflammatory and antinociceptive was evaluated using egg albumin induced paw edema and tail flick rat model respectively, at the dose of 400 mg/kg; while the antioxidant activity was evaluated in vitro using 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) scavenging and Ferric Reducing Antioxidant Power assay. The compounds produced various degrees of anti-inflammatory and antinociceptive activities but did not produce antioxidant effect. The sulphonamide derivative has anti-inflammatory and antinociceptive properties and can be used as drug for this purpose.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 5)
Pages:
74-78
DOI:
10.18052/www.scipress.com/IJPPE.5.74
Citation:
C. B. C. Ikpa et al., "Preliminary Screening for Anti-Inflammatory, Anti-Nociceptive and Antioxidant Activities of Five New Synthesized Paratoluene Sulphonamide Derivatives of Amino Acids", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 5, pp. 74-78, 2016
Online since:
Oct 2016
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