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Spasmolytic and Anti-Secretory Activities of Water/Ethanol Crinum jagus Extract

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The present study was undertaken to determine the potential anti-secretory and spasmolytic mechanism of Crinum jagus water/ethanol extract (25, 50 and 100 mg/kg, po). Anti-secretory activities were evaluated using castor oil and PGE2-induced enteropooling models in rats. Spasmolytic activities were conducted on small intestinal transit, on carbachol, 5-HT-induced intestine motility as well as on naloxone-pretreated intestine transit. C. jagus extract 25, 50 and 100 mg/kg bw has significantly (p<0.01) reduced in dose-dependent manner the castor oil-induced intestine secretion with inhibition rate of-59.7, -78.7 and-78.2% respectively. C jagus 25, 50 and 100 mg/kg bw water/ethanol extract induced significant (p< 0.01) dose-dependent reduction of PGE2-induced fluid accumulation, with inhibition rate of-16.9, -57.7 and-66.2% respectively. On intestine transit, as on carbachol and on serotonin-induced intestine motility, the extract significantly (P< 0.01) reduced the distance covered by the charcoal. The spasmolytic effect of C jagus extract was inhibited by the naloxone. These findings show that C jagus may reduce intestine secretion by the blockage of prostaglandins receptors. The spasmolytic effect could result from the blockage of muscarinic and/or serotonergic receptors, and by involving opiate receptors. These results support the traditional use of C jagus in gastrointestinal disorders treatment.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 5)
P. A. Noubissi et al., "Spasmolytic and Anti-Secretory Activities of Water/Ethanol Crinum jagus Extract", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 5, pp. 52-59, 2016
Online since:
October 2016

[1] M.G. Ignjatović, D. Kitić, M. Kostić, Spasmolytic effect of anethum graveolens L. methanol extract on isolated rat ileum, Acta Medica Median. 52 (2015) 5–10.


[2] R.K. Kumar et al., Evaluation of antidiarrhoeal activity of aqueous bulb extract of Allium cepa against castor oil-induced diarrhoea, Int. J. Herb. Med. 1 (2013) 64–67.

[3] P. Shamkuwar, Role of potassium channels, nitric oxide pathway and adrenergic receptors in antidiarrhoeal effect of mebarid, Asian J. Pharm. Clin. Res. 6 (2013) 295–296.

[4] A. Ogunkunle, O. Olopade, Studies on the asthma Coughs plant Crinum jagus L. (Amaryllidaceae) in Nigeria. African, J. Plant Sci. 5 (2011) 108–114.

[5] C. Mvongo et al., Phytochemical studies and in vitro antioxidant potential of two different extracts of Crinum jagus, Int. J. Pharm. Sci. Res. 6 (2015) 2354–2359.

[6] R. Kamgang et al., Antihyperglycemic potential of the water-ethanol extract of Kalanchoe crenata (Crassulaceae), J. Nat. Med. 62 (2008) 34–40.

[7] J. Smith et al., Working Grp, and "Principles and Practice in Ethical Review of Animal Experiments across Europe: Summary of the Report of a Felasa. Work, Gr. Ethical Eval. Anim. Exp. Lab. Anim. 41 (2007) 143–160.


[8] T.A.M. Fokam et al., Activity of Oxalis barrelieri aqueous extract on rat secretory diarrhea and intestine transit, J. Appl. Pharm. Sci. 5 (2015) 58–62.


[9] M.H. Mehmood et al., Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K + -channels activation, BMC Complement. Altern. Med. 15 (2015) 1–9.


[10] S.K. Prasad et al., Antidiarrhoeal evaluation of rhizomes of Cryptocoryne spiralis Fisch . ex Wydler : Antimotility and antisecretory effects, Indian J. Exp. Biol. 52 (2014) 139–146.

[11] S.L. Wansi et al., Antidiarrheal activity of aqueous extract of the stem bark of sapium ellipticum (Euphorbiaceae ), Trop. J. Pharm. Res. 13 (2014) 929–935.


[12] I. Dey, M. Lejeune, K. Chadee, Prostaglandin E2 receptor distribution and function in the gastrointestinal tract, Br. J. Pharmacol. 149 (2006) 611–623.


[13] S. Karaki, A. Kuwahara, Regulation of intestinal secretion involved in the interaction between neurotransmitters and prostaglandin E2, Neurogastroenterol Motil 16 (2004) 96–99.


[14] T. Unno et al., M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice, Br. J. Pharmacol. 146 (2005) 98–108.


[15] J. Strang, R. McDonald, Emergency naloxone in regular clinical practice, in: European Monitoring Centre for Drugs and Drugs Addiction, 2016, p.29–36.

[16] C. Faure, Role of Antidiarrheal Drugs as Adjunctive Therapies for Acute Diarrhea in Children, International Journal of Pediatrics. (2013) 1–14.

[17] N. Chetty, H.R. Irving, I.M. Coupar, Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study, Br. J. Pharmacol. 148 (2006) 1012-1021.

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[1] P. Noubissi, M. Fokam Tagne, G. Fankem, J. Ngakou Mukam, H. Wambe, R. Kamgang, "Effects of Crinum jagus Water/Ethanol Extract on Shigella flexneri-Induced Diarrhea in Rats", Evidence-Based Complementary and Alternative Medicine, Vol. 2019, p. 1, 2019