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Spasmolytic and Anti-Secretory Activities of Water/Ethanol <i>Crinum jagus </i>Extract
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Spasmolytic and Anti-Secretory Activities of Water/Ethanol Crinum jagus Extract

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Abstract:

The present study was undertaken to determine the potential anti-secretory and spasmolytic mechanism of Crinum jagus water/ethanol extract (25, 50 and 100 mg/kg, po). Anti-secretory activities were evaluated using castor oil and PGE2-induced enteropooling models in rats. Spasmolytic activities were conducted on small intestinal transit, on carbachol, 5-HT-induced intestine motility as well as on naloxone-pretreated intestine transit. C. jagus extract 25, 50 and 100 mg/kg bw has significantly (p<0.01) reduced in dose-dependent manner the castor oil-induced intestine secretion with inhibition rate of-59.7, -78.7 and-78.2% respectively. C jagus 25, 50 and 100 mg/kg bw water/ethanol extract induced significant (p< 0.01) dose-dependent reduction of PGE2-induced fluid accumulation, with inhibition rate of-16.9, -57.7 and-66.2% respectively. On intestine transit, as on carbachol and on serotonin-induced intestine motility, the extract significantly (P< 0.01) reduced the distance covered by the charcoal. The spasmolytic effect of C jagus extract was inhibited by the naloxone. These findings show that C jagus may reduce intestine secretion by the blockage of prostaglandins receptors. The spasmolytic effect could result from the blockage of muscarinic and/or serotonergic receptors, and by involving opiate receptors. These results support the traditional use of C jagus in gastrointestinal disorders treatment.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 5)
Pages:
52-59
DOI:
https://doi.org/10.18052/www.scipress.com/IJPPE.5.52
Citation:
P. A. Noubissi et al., "Spasmolytic and Anti-Secretory Activities of Water/Ethanol Crinum jagus Extract", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 5, pp. 52-59, 2016
Online since:
October 2016
Authors:
Paul Aimé Noubissi, Adela Ngwewondo, Michel Archange Fokam Tagne, Gaëtan Olivier Fankem, René Kamgang
Keywords:
Carbachol, Crinum jagus Extract, Enteropooling, Intestine Transit, Naloxone, PGE2, Rat, Serotonin
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Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

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Cited By:

[1] P. Noubissi, M. Fokam Tagne, G. Fankem, J. Ngakou Mukam, H. Wambe, R. Kamgang, "Effects of Crinum jagus Water/Ethanol Extract on Shigella flexneri-Induced Diarrhea in Rats", Evidence-Based Complementary and Alternative Medicine, Vol. 2019, p. 1, 2019

DOI: https://doi.org/10.1155/2019/9537603