Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

IJPPE > Volume 4 > Evaluation of Neuroprotective Effect of Ficus...
< Back to Volume

Evaluation of Neuroprotective Effect of Ficus benghalensis against Alloxan Induced Diabetic Neuropathy in Rats

Full Text PDF

Abstract:

Neuropathic pain in diabetics is characterized by both hyperalgesia and allodynia. This is attributed to both uncontrolled glycemia and the further complications which it leads to. The objective of the study was to evaluate the neuroprotective effect of methanolic leaf extract of Ficus benghalensis against alloxan induced diabetic neuropathy in rats.Material and methods:Experimental diabetes was induced in wistar albino rats by single intraperitoneal injection of Alloxan monohydrate (150 mg/kg). The methanolic extract of leaves of Ficus benghalensis at a dose of 200 and 400 mg/kg body weight was administered at single dose per day to diabetes induced rats for a period of 28 days. Neuropathic pain was assessed in diabetic rats with various painful procedures. hot and cold water tail immersion test, pinprick test, cold allodynia, hot plate test, actophotometer and rota-rod tests were performed to assess the degree of thermal, mechanical, cold hyperalgesia and locomotor activity as well as motor co-ordination.Results:Animals treated with methanolic extract of Ficus benghalensis (200, and 400 mg/kg p.o.) showed good results in different parameters such as thermal allodynia (hot and cold), thermal hyperalgesia and motor co-ordination in comparison with diabetic control group. Thus, from this study we conclude that Ficus benghalensis exhibits significant neuroprotective activities against Alloxan-induced diabetic neuropathy in rats.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 4)
Pages:
52-60
DOI:
10.18052/www.scipress.com/IJPPE.4.52
Citation:
C. Stalin et al., "Evaluation of Neuroprotective Effect of Ficus benghalensis against Alloxan Induced Diabetic Neuropathy in Rats", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 4, pp. 52-60, 2016
Online since:
Aug 2016
Export:
Distribution:
References:

[1] L. Packer, K. Kraemer, G. Rimbach, Molecular aspects of lipoic acid in the prevention of diabetes complications, Nutrition 17 (2001) 888-895.

[2] M. Farswan, P.M. Mazumder, V. Percha, Protective effect of Cassia glauca Linn. On the serum glucose and hepatic enzymes level in streptozotocin induced NIDDM in rats, Indian J. Pharmacol. 41 (2009) 19-22.

[3] J.H. Lee, D.J. Cox, D.G. Mook, R.C. McCarty, Effect of hyperglycemia on pain threshold in alloxan-diabetic rats, Pain. 40 (1990) 105-107.

[4] J. Kastrup et al., Intravenous lidocaine infusion – a new treatment of chronic painful diabetic neuropathy?, Pain. 28 (1987) 69-75.

[5] M. Brownlee, Biochemistry and molecular cell biology of diabetic complications, Nature. 414(6865) (2001) 813-820.

[6] M. Anjaneyulu, K. Chopra, Quercetin attenuated thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats, Indian Journal of Experimental Biology. 42 (2004) 766-769.

[7] J. Kastrup et al., Intravenous lidocaine infusion – a new treatment of chronic painful diabetic neuropathy?, Pain. 28 (1987) 69-75.

[8] Tesfaye et al., Painful diabetic peripheral neuropathy: Consensus recommendations on diagnosis, assessment and management, Diabetes Metabol. Res. Rev. 27 (2011) 629-638.

[9] S.O. Kim, H.J. Kim, Berberine ameliorates cold and mechanical allodynia in a rat model of diabetic neuropathy, J. Med. Food. 16 (2013: 511-517.

[10] P.M. Subramanian, G.S. Misra, Chemical constituents of Ficus benghalensis, Polish Journal of Pharmacology and Pharmacy. 30 (4) (1978) 559-562.

[11] P.K. Mukherjee et al., Screening of antidiarrhoeal profile of some plant extracts of a specific region of West Bengal, India, Journal of Ethnopharmacology. 60 (1) (1998) 85-89.

[12] A. Husain et al., Dictionary of Indian Medicinal Plants, CIMAP, Lucknow, India, (1992).

[13] M.N. Aiyer, A.N. Namboodiri, M. Kolammal, Pharmacognosy of Ayurvedic drugs, Trivandrum (1957).

[14] P.K. Warrier, VPK Nambiar, C. Ramankutty, Indian Medicinal Plants, (1-5) Orient Longman Ltd., Madras, (1995).

[15] S.Y. Gabhe, P.A. Tatke, T.A. Khan, Evaluation of the immunomodulatory activity of the methanol extract of Ficus benghalensis roots in rats, Indian Journal of Pharmacology. 38 (4) (2006) 271-275.

[16] K.T. Augusti, Hypoglycemic action of bengalenoside, a glucoside isolated from Ficus benghalensis Linn, in normal and alloxan diabetic rabbits, Indian Journal of Physiology and Pharmacology. 19(4) (1975) 218-220.

[17] S. Achrekar, G.S. Kaklij, M.S. Pote, S.M. Kelkar, Hypoglycemic activity of Eugenia jambolana and Ficus benghalensis: mechanism of action, In Vivo. 5(2) (1994) 143-147.

[18] S. Ghosh, S.A. Suryawanshi, Effect of Vinca rosea extract in treatment of alloxan diabetes in male albino rats, Indian J. Expt. Biol. 39 ( 2001) 748-759.

[19] C.R. Reshmi, A. Fatima, B. Sinilal, MS Latha, Antidiabetic effect of herbal drug in Alloxan diabetic rats, Indian Drugs. 38 (2001) 319-322.

[20] N. Attal, F. Jazat, V. Kayser, G. Guilbaud, Further evidence for pain-related behaviours in a model of unilateral peripheral mononeuropathy. Pain. 41 (1990) 235-251.

[21] S.A. Kanaan et al., Endotoxin-induced local inflammation and hyperalgesia in rats and mice: A new model for inflammatory pain, Pain. 66 (1996) 373-379.

[22] Y. Choi et al., Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain, Pain. 59 (1995) 369-376.

[23] R.J. Carter, J. Morton, S.B. Dunnett, Motor coordination and balance in rodents, Curr Protoc Neurosci. (2001) 8-12.

[24] A. Kar, B.K. Choudhary, N.G. Bandyopadhyay, Comparative evaluation of hypoglycemic activity of some Indian medicinal plants in alloxan diabetic rats, J. Ethnopharmacol. 84 (2003) 105-108.

[25] E.N.M. Claudia, E.O. Julius, T. Dagobert, D. Etienne, Antidiabetic and Hypolipidemiceffects of Laporteaovalifolia (URTICACEAE) in alloxan induced diabeticrats, Afr. J. Tradit. Complement. Altern. Med. 3(1) (2006) 36-43.

[26] B. Aubel et al., Antihyperalgesic effects of cizolirtine in diabetic rats: behavioral and biochemical studies, Pain. 110 (2004) 22-32.

Show More Hide