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Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres

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Abstract:

Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R2 = 0.9987) during desorption of LC upto 30 minutes at 25 °C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 4)
Pages:
36-46
DOI:
10.18052/www.scipress.com/IJPPE.4.36
Citation:
M. Ashaduzzaman et al., "Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 4, pp. 36-46, 2016
Online since:
Aug 2016
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