Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

IJPPE > Volume 4 > Studies on Interaction of Lidocaine Drug with...
< Back to Volume

Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres

Full Text PDF


Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R2 = 0.9987) during desorption of LC upto 30 minutes at 25 °C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 4)
M. Ashaduzzaman et al., "Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 4, pp. 36-46, 2016
Online since:
Aug 2016

[1] S. Perez, D. Samain, Structure and engineering of celluloses, Adv. Carbohydr, Chem. Biochem. 64 (2010) 5-116.

[2] M. Z. Rong et al., The effect of fiber treatment on the mechanical properties of unidirection sisal-reinforced epoxy composites, Compos. Sci. Technol. 61 (2001) 1437-1447.

[3] E. I. Filpponen, The synthetic strategies for unique properties in cellulose nanocrystal materials, PhD Thesis, 2009; North Carolina State University, Page 1. URI: http: /www. lib. ncsu. edu/resolver/ 1840. 16/4626.

[4] D. Wandera, S. R. Wickramasinghe, S. M. Husson, Stimuli-responsive membranes, J. Membr. Sci. 357 (2010) 6–35.

[5] Y. Nishio, Material functionalization of cellulose and related polysaccharides via diverse microcompositions, Adv. Polym. Sci. 205 (2006) 97-151.

[6] A. Carlmark, E. E. Malmstrom, ATRP Grafting from Cellulose Fibers to Create Block-Copolymer Grafts, Biomacromol. 4 (2003) 1740-1745.

[7] B. Biswal, J. Anurekha, Drug-excipient Interaction Study for Apple Cider Vinegar with 20 Potential Excipients using Modern Analytical Techniques, Asian J. Pharma. 10(1) (2016) 65-71.

[8] P. Crowley, L. G. Martini, Drug–Excipient Interaction. Pharmaceutical Technology Europe, Advanstar. (2001) 0582.

[9] S. A. Muratova et al., Studying interactions in microcrystalline-drug systems, Pharm. Chem. J. 36 (2002) 619-621.

[10] R. Fangueiro, S. Rana, Natural Fibres: Advances in Science and Technology Towards Industrial Applications, (Edited) Springer, (2016).

[11] R. Kolakovic et al., Evaluation of drug interactions with nanofibrillar cellulose, Eur J Pharm Biopharm. 85 (2013) 1238-44.

[12] N. D. Burkhanova et al., Interaction of drugs with microcrystalline cellulose at the molecular and supramolecular levels. Chem. Nat. Comp. 33(3) (1997) 440-446.

[13] S. Al-Nimry, S. Assaf, I. Jalal, N. Najib, Adsorption of ketotifen onto some pharmaceutical excipients, Int. J. Pharm. 149 (1997) 115-121.

[14] M.S. El-Samaligy, G.M. El-Mahrouk. T.A. El-Kirsh, Adsorption-desorption effect of microcrystalline cellulose on ampicillin and amoxicillin, Int. J. Pharm. 31 (1986) 137-144.

[15] R.M. Franz, G.E. Peck, In vitro adsorption –desorption of fluphenazine dihydrochloride and promehazine hydrochloride by microcrystalline cellulose, J. Pharm. Sci. 71 (1982) 1193-1199.

[16] D. N. T. Kumar et al., Purified and Bio-polished Cotton Fibers as DNA-Streptavidin Tags for Bio-applications, using a Novel Approach, Inter. J. Eng. Res. Appl. (2012) 1117-1123.

[17] A. Cavaco–Pauloa, J. Morgadoa, J. Andreausb, D. Kilburn, Interactions of cotton with CBD peptides, Enzy. Micro. Technol. 25 (1999) 639–643.

[18] A. R. Khan, H. Tahir, F. Uddin, U. Hameed, Adsorption of Methylene Blue from aqueous Solution on the Surface of Wool Fiber and Cotton Fiber, J. Appl. Sci. Environ. Mgt. 9(2) (2005) 29 – 35.

[19] C. Kaewprasit, E. Hequet, N. Abidi, J. P. Gourlot, Application of Methylene Blue Adsorption to Cotton Fiber Specific Surface Area Measurement: Part I. Methodology, J. Cott. Sci. 2 (1998) 164-173.

[20] S. Okada, H. Nakahara, H. Isaka, Adsorption of drugs on microcrystalline cellulose suspended in aqueous solutions, Chem. Pharm. Bull. 35 (1987) 761-768.

[21] P. W. Atkins, Physical chemistry, (5th Edition) Oxford university press, Oxford. (1994) pp.986-993.

[22] M. E. Aulton, Pharmaceutics The science of dosage form design, Churchill Livingstone. London. (58-61) (2000) 616-628.

[23] M. Bagane, S. Guiza, Removal of a dye from textile effluents by adsorption, Ann. Chim. Sci. Mater. 25 (2000) 615-626.

[24] G. Rytwo, S. Nir, M. Crespin, L. Margulies, Adsorption and Interactions of Methyl Green with Montmorillonite and Sepiolite, J. Col. Inter. Sci. 222 (2000) 12-19.

[25] C. H. Giles, T. H. MacEwan, S. N. Nakhva, D. Smith, Studies in adsorption. Part XI. A system of classification of solution adsorption isotherms, and its use in diagnosis of adsorption mechanisms and in measurement of specific surface areas of solids, J. Chem. Soc. 56 (1960).

Show More Hide