Diabetes is a chronic metabolic disease, which affects large number of population all over the world. Diabetes is associated with many complications as dyslipidemia, coronary heart diseases and non alcoholic fatty liver diseases. More than 400 traditional medicinal plants have been recorded for helping in controlling such disease. This review discusses the effects of most common plants (Foenugreek, Nigella and Termis) used in Saudi Arabia and some other Arab countries as antidiabetic agents. The usage of the mixture or each plant alone corrected the blood glucose level and increase insulin secretion with definite increase in the number and diameter of beta pancreatic cells in the diabetic rats. Also, improve the associated dyslipidemia, and ameliorated most of all damage effects of Alloxan on hematological parameters present in diabetic rats. So, it can control most of the metabolic risk factors of coronary artery disease (CAD) in diabetic. Finally, it appeared to be a useful agent in improving fatty changes in the liver texture associated with DM. It can be concluded that, water extract of the mixture of Foenugreek, Nigella and Termis is the most powerful in amelioration hyperglycemia, dyslipidemia and most of all damage effects of Alloxan on the liver and hematological parameters.
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 3)
W. S. Mohamed "Metabolic Effects of Foenugreek, Nigella and Termis: Review Article", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 3, pp. 90-96, 2016