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Analysing the Hypolipidemic Activities of the Tea Extracts of Moringa oleifera, Glycyrrhiza glabra and their Blend at Different Concentrations, Orally Induced on Adult Male Wistar Rats.

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Abstract:

Herbal teas of Moringa oleifera (Moringa) and Glycyrrhiza glabra (Licorice) were known to have many beneficial effects, their possible hypolipidemic effects were investigated in this paper. Albino wistar rats were fed with aqueous extracts of M. oleifera, G. glabra and their blend teas (10, 30 and 50 mg/kg.BW/ml). The teas were found to lower the serum cholesterol, triglycerides, VLDL, LDL, and atherogenic index at their higher concentration, but were found to slightly increase the HDL as compared to the corresponding normal healthy rats fed with clean water (control). The phytochemicals screening of the teas aqueous extract were also investigated, the chemicals (tannins, saponins, flavonoids, terpenoids and glycosides) which were known to exhibit cholesterol lowering effect by inhibiting its absorption and simultaneous increase its excretion were found to be present in the teas extract. Thus, the study demonstrates and validates that M. oleifera, G. glabra and their blend possess hypolipidemic effect at higher concentration.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 3)
Pages:
76-83
Citation:
O. R. Akinseye "Analysing the Hypolipidemic Activities of the Tea Extracts of Moringa oleifera, Glycyrrhiza glabra and their Blend at Different Concentrations, Orally Induced on Adult Male Wistar Rats.", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 3, pp. 76-83, 2016
Online since:
Jun 2016
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[1] ICW Arts, and PCH Hollman. Polyphones and disease risk in epidemiologic studies. Am J Clin Nutr 81 (2005): 317–325.

[2] O. Benavente-Garcia, J. Castillo, FR. Marin, A. Ortuño, and JA. Del-Rio. Uses and properties of Citrus flavonoids. J. Agric. Food Chem 45 (1997) : 4505-4515.

[3] SS. Bhatnagar, H. Santapau, JDH Desai, S. Yellore, TNS. Rao. Biological activity of Indian medicinal plants. Part 1. Antibacterial, antitubercular and antifungal action. Indian J Med Res 49 (1961) : 799-805.

[4] S. R. Chanda and Daveet. In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview. Afr J Microbiol Res 3(13) (2009): 981-996.

[5] YC Chung, CT Chang, WW Chao, CF Lin, and ST Chou. Antioxidative activity and safety of the 50% ethanol extract from red bean fermented by Bacillus subtilis IMR-NK1. J. Agric. Food Chem 50 (2002) : 2454-(2058).

[6] J Dai, and RJ Mumper. Plant phenolics: Extraction, analysis and their antioxidant and anticancer properties. Molecules 15 (2010) : 7313–52.

[7] S Faizi, BS Siddiqui, R Saleem, K Aftab, F Shaheen, AH Gilani. Hypotensive constituents from the pods of Moringa oleifera. Planta Med 64 (1998) : 225-228.

[8] T Fukai, K Satoh, T Nomura, H Sakagami. Preliminaryevaluation of antinephritis and radical scavenging activitiesof glabridin from Glycyrrhizaglabra. Fitoterapia; 74 (2003) : 624-9.

[9] E. Gumpricht; R. Dahl; M.W. Devereaux; J.S. Ronald. Licorice compounds glycyrrhizin and 18β-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. J. Biol. Chem., 280, (2005) 10556–10563.

[10] T. Hartmann. From waste products to ecochemicals: Fifty years research of plant secondary metabolism. Phytochemical. 2007;68: 2831–46. [PubMed: 17980895].

[11] H. Jenke Kodama, R. Müller, E. Dittmann. Evolutionary mechanisms underlying secondary metabolite diversity. Prog Drug Res. 2008. p.121–40. [PubMed: 18084914].

[12] R. Johnson, P. McNutt, S. MacMahon, R. Robson. Use of the friedewald formula to estimate LDL-cholesterol in patients with chronic renal failure on dialysis. Clin Chem 43 (1997): 2183-2184.

[13] RV Karadi, NB Gadge, KR Alagawadi, RV Savadi. Effect of Moringa oleifera root wood on ethylene glycol induced urolithiasis in rats. J Ethnopharmacol 105 (2006): 306-311.

[14] CK Kokate. Practical Pharmacognosy. Vallabh Prakashan, New Delhi, (1994) 107-111.

[15] YM Li, XG Zhang, HL Zhou, SH Chen, Y Zhang, CH Yu. Effects of tea polyphenols on hepatic fibrosis inrats with alcoholic liver disease. HepatobiliaryPancreat Dis Int.; 3 (2004) : 577–579. [PubMed].

[16] LK Mehta, R. Balaraman, AH Amin, PA Bafna, OD Gulati. Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. J Ethnopharmacol 86 (2003): 191-195.

[17] S. Muruganandan, K. Srinivasan, S. Gupta, PK Gupta, J. Lal. Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnopharmacol 97 (2005): 497-501.

[18] M. Naczk and F. Shahidi. Extraction and analysis of phenolics in food. J Chromatogr A 1054 (2004) : 95–111.

[19] K. Nantachit. Antibacterial activity of the capsule of Moringa oleifera. CMU J Nat Sci 5 (2006) : 365-368.

[20] K. Raida, A. Nizar, S. Barakat. The Effect of Crataegus aronica aqueous extract in rabbits fed with high cholesterol diet. Eur J Sci Res 22 (2008) : 352-360.

[21] M. Rahnama; D. Mehrabani; S. Japoni; M. Edjtehadi; M.S. Firoozi. The healing effect of licorice (Glycyrrhiza glabra) on Helicobacter pylori infected peptic ulcers. J. Res. Med. Sci., 18 (2013), 532–533.

[22] BS Rathi, SL Bodhankar, AM Baheti. Evaluation of aqueous extract of Moringa oleifera for wound healingin albino rats. Indian J Exp Biol 44 (2006): 898-901.

[23] J. Reuter, I. Merfort, CM Schempp. Botanicals in dermatology: an evidence-based review., American Journal of Clinical Dermatology 11 (4) (2010): 247-67.

[24] D. Satheeshkumar , A. Kottai Muthu, and R. Manavalan. Antioxidant potential of various extracts from whole plant of Ionidium suffruticosum (Ging). Res. J. Pharm., Biol. Chem. Sci 2 (3) (2011) : 286-293.

[25] MP Saluja, RS Kapil, SP Popli. Studies in medicinal plants: part VI. Chemical constituents of Moringa oleifera Lam. (hybrid variety) and isolation of 4-hydroxymellein. Indian J Chem B 16B (1978) : 1044-1045.

[26] A. Scalbert, C. Morand, C. Manach, and C. R´em´esy. Absorption and metabolism of polyphenols in the gut and impact on health. Biomed Pharmacother 56 (2002) : 276–82.

[27] M.A. Takhshid; D. Mehrabani; J. Ai; M. Zarepoor. The healing effect of licorice extract in acetic acid-induced ulcerative colitis in rat model. Comp. Clin. Pathol. , 21, (2012) 1139–1144.

[28] A. Tanaka; M. Horiuchi; K. Umano; S. Takayuki. Antioxidant and antiinflammatory activities of water distillate and its dichloromethane extract from licorice root (Glycyrrhiza uralensis) and chemical composition of dichloromethane extract. J. Sci. Food Agric., 88, (2008).

[29] CR Tenpe, AB Thakre, AB Upaganlawar, PG Yeole. Hypolipidemic and weight controlling activity of Terminalia catappa in rats on sucrose high fat diet. Indian Drugs 44 (2006): 16-20.

[30] GE Trease, MC Evans. Textbook of Pharmacognosy. 12th edition, Balliere Tindall, (1983) pp: 343-383.

[31] P. Veeru1, PK Mishra and M Mishra. Screening of medicinal plant extracts for antioxidant Activity. J Med Plant Res 3(8) (2009) : 608-612.

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