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The Islet Confidential: Recent Trends and Perspectives in Pancreatic Islet Transplantation

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Abstract:

Diabetes ranks among the top 5 killer diseases of the current world population. Transplantation of pancreatic islets is a common surgical procedure used to combat the late stage diabetic complications. A successful and long lasting islet transplant is an enigma as the complex immunoactivation mechanisms against the transplants, the subsequent graft rejection and the proper maturation and functioning of the islets in the host microenvironment, are the subjects of research for many years. This review details certain recent studies performed upon primate, porcine, murine and rabbit models, in relation to islet transplantation, with a critical standpoint.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 3)
Pages:
54-75
Citation:
B. Radha et al., "The Islet Confidential: Recent Trends and Perspectives in Pancreatic Islet Transplantation", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 3, pp. 54-75, 2016
Online since:
June 2016
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References:

[1] Poitout, Vincent, and R Paul Robertson, Glucolipotoxicity : Fuel excess and β -cell dysfunction. Endocrine Reviews 2008; 29: 351–66.

DOI: https://doi.org/10.1210/er.2007-0023

[2] S. Jitrapakdee, A. Wutthisathapornchai, J. C. Wallace, and M. J. MacDonald, Regulation of insulin secretion: role of mitochondrial signaling. Diabetologia 2010; 53, 1019–32.

[3] Jingbo Pi, Qiang Zhang, Jingqi Fu, Courtney G. Woods, Yongyong Hou, Barbara E Corkey, Sheila Collins, and Melvin E. Andersen, ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicology and Applied Pharmacology 2011; (244), 77–83.

[4] Carl Jorgen Hedeskov and Kirsten Capito, The Pentose Cycle and Insulin Release in Isolated Mouse Pancreatic Islets during Starvation. Biochemical Journal 1975; 152: 571-576.

DOI: https://doi.org/10.1042/bj1520571

[5] M. J. Shapiro, J. R. T. Lakey, E. A. Ryan et al., Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. The New England Journal of Medicine 2000; vol. 343, no. 4, p.230–238.

DOI: https://doi.org/10.1056/nejm200007273430401

[6] Chand S, A J Mcknight, S Shabir, W Chan, J A Mccaughan, A P Maxwell, and others, Analysis of Single Nucleotide Polymorphisms Implicate mTOR Signalling in the Development of New-Onset Diabetes after Transplantation. BBACLI 2016; 5: 41–45.

[7] Bijkerk Roel, Pieter Van Der Pol, and Meriem Khairoun, Simultaneous Pancreas – Kidney Transplantation in Patients with Type 1 Diabetes Reverses Elevated MBL Levels in Association with MBL2 Genotype and VEGF Expression. Diabetologia 2016; 853–58.

[8] Nicholls Susan, Ricardo Pong-wong, Louisa Mitchard, Ross Harley, Alan Archibald, Andrew Dick, and others, Genome-Wide Analysis in Swine Associates Corneal Graft Rejection with Donor-Recipient Mismatches in Three Novel Histocompatibility Regions and One Locus Homologous to the Mouse H-3 Locus. PLos ONE 2016; 1–12.

[9] Torren Cornelis R Van Der, Arnaud Zaldumbide, Dave L Roelen, Gaby Duinkerken, Simone H Brand-schaaf, Mark Peakman, and others, Innate and Adaptive Immunity to Human Beta Cell Lines : Implications for Beta Cell Therapy. Diabetologia 2016; 170–75.

DOI: https://doi.org/10.1007/s00125-015-3779-1

[10] Zhang Xiaohai, Nicole M Valenzuela, and Elaine F Reed, HLA class I antibody-mediated endothelial and smooth muscle cell activation. Curr Opin Organ Transplant 2012; August: 17(4).

DOI: https://doi.org/10.1097/mot.0b013e328355f1c2

[11] Harper Ines G, Jason M Ali, Simon J F Harper, Menna R Clatworthy, Thomas M Conlon, Gavin J Pettigrew, and others, Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant Article Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant. Cell Reports 2016; 1–14.

DOI: https://doi.org/10.1016/j.celrep.2016.04.009

[12] Wang Nan, Narendiran Rajasekaran, Tieying Hou, Claudia Macaubas, and D Mellins, Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation. PLos ONE 2015; 1–16.

DOI: https://doi.org/10.1371/journal.pone.0128494

[13] Rodríguez-castelán Julia, Margarita Martínez-gómez, Francisco Castelán, and Estela Cuevas, Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of Endocrinology 2015; 19–21.

DOI: https://doi.org/10.1155/2015/917806

[14] Malihe-Sadat Poormasjedi-Meibod, Raza B. Jalili, Azadeh Hosseini-Tabatabaei, Ryan Hartwell, Aziz Ghahary, Immuno-Regulatory Function of Indoleamine 2 , 3 Dioxygenase through Modulation of Innate Immune Responses. PLos ONE 2013; Volume 8, Issue 8, e71044.

[15] Zhan Yang, Yeming Han, Hukui Sun, Ting Liang, Chao Zhang, and Jing Song, T Cells Prolongs Allograft Survival. Oncotarget 2016; 767491.

DOI: https://doi.org/10.18632/oncotarget.8804

[16] Nagy Nadine, Gernot Kaber, Pamela Y Johnson, John A Gebe, Anton Preisinger, Ben A Falk, and others, Inhibition of Hyaluronan Synthesis Restores Immune Tolerance during Autoimmune Insulitis. The Journal of Clinical Investigation 2015; Volume 125 Number 10.

[17] Bogdani Marika, Pamela Y Johnson, Susan Potter-perigo, Nadine Nagy, and Anthony J Day, Hyaluronan and Hyaluronan- Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis. Diabetes 2014; 63: 2727–2743.

DOI: https://doi.org/10.2337/db13-1658

[18] Bogdani Marika, Charmaine Simeonovic, Nadine Nagy, Pamela Y Johnson, K Chan, and Thomas N Wight, The Detection of Glycosaminoglycans in Pancreatic Islets and Lymphoid Tissues. Methods Mol Biol 2015; 1229: 413–430.

DOI: https://doi.org/10.1007/978-1-4939-1714-3_32

[19] Paudel Suresh, Ioannis M Zacharioudakis, Fainareti N Zervou, Panayiotis D Ziakas, and Eleftherios Mylonakis, Prevalence of Clostridium difficile Infection among Solid Organ Transplant Recipients : A Meta-Analysis of Published Studies. PLos ONE 2015; 1–16.

DOI: https://doi.org/10.1371/journal.pone.0124483

[20] Kim Sung-Han, Hyun-jeong Lee, Sun-mi Kim, Joo Hee Jung, Sung Shin, Young Hoon Kim, and others, Diagnostic Usefulness of Cytomegalovirus ( CMV ) - Specific T Cell Immunity in Predicting CMV Infection after Kidney Transplantation : A Pilot Proof-of- Concept Study. Infect Chemother 2015; 47(2): 105-110.

DOI: https://doi.org/10.3947/ic.2015.47.2.105

[21] Sue Paul K, Nora Pisanic, Christopher D Heaney, Michael Forman, Alexandra Valsamakis, Annette M Jackson, and others, Hepatitis E Virus Infection Among Solid Organ Transplant Recipients at a North American Transplant Center. Open Forum Infectious Diseases 2012; 1–8.

[22] Chedid Marcio F, Leandro A Scaffaro, Aljamir D Chedid, Antonio C Maciel, Carlos Thadeu S Cerski, Matheus J Reis, and others, Transarterial Embolization and Percutaneous Ethanol Injection as an Effective Bridge Therapy before Liver Transplantation for Hepatitis C-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice 2016; Article ID 9420274, 5 pages.

DOI: https://doi.org/10.1155/2016/9420274

[23] Saab Sammy, Justin Rheem, Melissa Jimenez, Sherona Bau, Gina Choi, Francisco Durazo, and others, Curing Hepatitis C in liver transplant recipients is associated with changes in Immunosuppressant use. Journal of Clinical and Translational Hepatology 2016; 4: 32–38.

DOI: https://doi.org/10.14218/jcth.2016.00070

[24] Alan D. Agulnick, Dana M. Ambruzs, Mark A. Moorman, Anindita Bhoumik, Rosemary M. Cesario, Janice K. Payne, Jonathan R. Kelly, Carl Haakmeester, Robert Srijemac, Alistair Z. Wilson, Justin Kerr, Mauro A. Frazier, Evert J. Kroon, Kevin A. D'amour, Tissue Engineering and Regenerative Medicine, Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo. Stem Cells Translational Medicine 2015; 4: 1214–1222.

DOI: https://doi.org/10.5966/sctm.2015-0079

[25] Pepper Andrew R, Rena Pawlick, Boris Gala-lopez, Amanda Macgillivary, Delfina M Mazzuca, David J G White, and others, Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device. Transplantation 2015; 99: 2294–2300.

DOI: https://doi.org/10.1097/tp.0000000000000864

[26] Yap Woon Teck, Xiaomin Zhang, Zachary G Bannon, Dixon B Kaufman, William L Lowe, and Lonnie D Shea, Collagen IV-Modified Scaffolds Improve Islet Survival and Function and Reduce Time to Euglycemia. Tissue Engineering: Part A 2013; Volume 19, Numbers 21 and 22.

DOI: https://doi.org/10.1089/ten.tea.2013.0033

[27] McBane Joanne E, Branka Vulesevic, Donna T Padavan, Kimberly A Mcewan, S Gregory, and Erik J Suuronen, Evaluation of a Collagen-Chitosan Hydrogel for Potential Use as a Pro-Angiogenic Site for Islet Transplantation. PLos ONE 2013; 8: 1–15.

DOI: https://doi.org/10.1371/journal.pone.0077538

[28] Ehrhart Friederike, Esther Mettler, Thomas Böse, Matthias Max Weber, and Julio Alberto Vásquez, Biocompatible Coating of Encapsulated Cells Using Ionotropic Gelation. PLos ONE 2013; 8: 1–9.

[29] Kuehn Carina, Jonathan R T Lakey, Morgan W Lamb, and Patrick Vermette, Young Porcine Endocrine Pancreatic Islets Cultured in Fibrin Show Improved Resistance toward Hydrogen Peroxide. Islets 2013; 207–15.

[30] Guerreiro Luiz Henrique, Mariana F A N Guterres, Bruno Melo-ferreira, Luiza C S Erthal, Silva Rosa, Daniela Lourenço, and others, Preparation and Characterization of PEGylated Amylin. AAPS Pharm. SciTech 2013; Vol. 14, No. 3.

DOI: https://doi.org/10.1208/s12249-013-9987-4

[31] Yamashita Shingo, Kazuo Ohashi, Rie Utoh, Teruo Okano, and Masakazu Yamamoto, Human Laminin Isotype Coating for Creating Islet Cell Sheets. Cell Medicine 2015; 8: 39–46.

DOI: https://doi.org/10.3727/215517915x689029

[32] Willenberg Bradley J, Jose Oca-cossio, Yunqing Cai, Alicia R Brown, William L Clapp, Dale R Abrahamson, and others, Repurposed Biological Scaffolds : Kidney to Pancreas. Organogenesis 2015; 47–57.

DOI: https://doi.org/10.1080/15476278.2015.1067354

[33] Okawa Hiroko, Hiroki Kayashima, Jun-ichi Sasaki, Jiro Miura, Yuya Kamano, Yukihiro Kosaka, and others, Scaffold-Free Fabrication of Osteoinductive Cellular Constructs Using Mouse Gingiva-Derived Induced Pluripotent Stem Cells. Stem Cells International 2016; Article ID 6240794, 11 pages.

DOI: https://doi.org/10.1155/2016/6240794

[34] Sayed-Hadi Mirmalek-Sani, Giuseppe Orlando, John McQuilling, Rajesh Pareta, David Mack, Marcus Salvatori, Alan C Farney, Robert J Stratta, Anthony Atala, Emmanuel C Opara, and Shay Soker, Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials 2013; July; 34(22): 5488–5495.

DOI: https://doi.org/10.1016/j.biomaterials.2013.03.054

[35] Johansson Ulrika, Massimiliano Ria, Å Karin, and Nancy Dekki Shalaly, Pancreatic Islet Survival and Engraftment Is Promoted by Culture on Functionalized Spider Silk Matrices. PLos ONE 2015; 1–21.

DOI: https://doi.org/10.1371/journal.pone.0130169

[36] Wu Di, Jian Wan, Yan Huang, Yibing Guo, Tianxin Xu, Mingyan Zhu, and others, 3D Culture of MIN-6 Cells on Decellularized Pancreatic Scaffold : In Vitro and In Vivo Study. BioMed Research International 2015; Article ID 432645, 8 pages.

DOI: https://doi.org/10.1155/2015/432645

[37] Schmidt CE, Baier JM., Acellular vascular tissues: Natural biomaterials for tissue repair and tissue engineering. Biomaterials 2000; Nov. 21(22): 2215-31.

DOI: https://doi.org/10.1016/s0142-9612(00)00148-4

[38] Cavallo J A, S C Greco, J Liu, M M Frisella, C R Deeken, and B D Matthews, Remodeling characteristics and biomechanical properties of a crosslinked versus a non-crosslinked porcine dermis scaffolds in a porcine model of ventral hernia repair. Hernia 2015; April ; 19(2): 207–218.

DOI: https://doi.org/10.1007/s10029-013-1070-2

[39] Dardik H, Miller N, Dardik A, Ibrahim I, Sussman B, Berry SM, Wolodiger F, Kahn M, Dardik I, A decade of experience with the glutaraldehyde-tanned human umbilical cord vein graft for revascularization of the lower limb. J Vasc Surg 1988; Feb; 7(2): 336-46.

DOI: https://doi.org/10.1067/mva.1988.avs0070336

[40] Saeromi Jeong, Eun Jung Yoon, Hong Gook Lim, Si Chan Sung, and Yong Jin Kim, The Effect of Space Fillers in the Cross-Linking Processes of Bioprosthesis. BioResearch Open Access 2013; Vol : 2, 2.

DOI: https://doi.org/10.1089/biores.2012.0289

[41] Chang Y, Tsai CC, Liang HC, Sung HW, In Vivo evaluation of cellular and acellular pericardia fixed with a naturally occurring crosslinking agent (Genipin). Biomaterials 2002; Jun; 23(12): 2447-57.

DOI: https://doi.org/10.1016/s0142-9612(01)00379-9

[42] Jiang T, Ren XJ, Tang JL, Yin H, Wang KJ, Zhou CL, Preparation and characterization of Genipin-crosslinked rat acellular spinal cord scaffolds. Mater Sci Eng C Mater Biol Appl 2013; Aug 1; 33(6): 3514-21.

DOI: https://doi.org/10.1016/j.msec.2013.04.046

[43] Thomas Vinoy, Danna Nozik, Harsh Patel, Raj K Singh, Yogesh K Vohra, and Avenue South, Biohybrid Fibro-Porous Vascular Scaffolds: Effect of Crosslinking on Properties. Mater Res Soc Symp Proc. 2015; 1718.

DOI: https://doi.org/10.1557/opl.2015.490

[44] Wang Yujia, Ji Bao, Xiujuan Wu, Qiong Wu, Yi Li, Yongjie Zhou, and others, Genipin Crosslinking Reduced the Immunogenicity of Xenogeneic Decellularized Porcine Whole- Liver Matrices through Regulation of Immune Cell Proliferation and Polarization. Scientific Reports 2016; 1–16 . DOI: 10. 1038/srep24779.

DOI: https://doi.org/10.1038/srep24779

[45] Andreas M. Nyström and Karen L. Wooley, Thiol-functionalized shell crosslinked knedel-like (SCK) nanoparticles: A versatile entry for their conjugation with biomacromolecules. Tetrahedron 2008; September 1; 64(36): 8543–8552.

DOI: https://doi.org/10.1016/j.tet.2008.04.104

[46] M. El-Sherbiny and H. D. C. Smyth, Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I)Self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres. Int J Pharm 2010; August 16; 395.

DOI: https://doi.org/10.1016/j.ijpharm.2010.05.032

[47] Tripathi Rahul, and Brahmeshwar Mishra, Development and Evaluation of Sodium Alginate – Polyacrylamide Graft – Co-Polymer- Based Stomach Targeted Hydrogels of Famotidine . AAPS 2012; 13.

[48] Tania Betancourt, Juan Pardo, Ken Soo, and Nicholas A. Peppas, Characterization of pH-Responsive Hydrogels of Poly(Itaconic acid-g-Ethylene Glycol) Prepared by UV-Initiated Free Radical Polymerization as Biomaterials for Oral Delivery of Bioactive Agents. J Biomed Mater Res A 2010; April ; 93(1): 175–188.

DOI: https://doi.org/10.1002/jbm.a.32510

[49] Wang Qinmei, and Qiong Wang, Hydrogels Containing Conductive Polymer Nanoparticles for Biomedical Applications. International Journal of Nanomedicine 2016; 11: 131–145.

DOI: https://doi.org/10.2147/ijn.s94777

[50] Yeom Junseok, Byung Woo Hwang, Dong Jun Yang, Hong-in Shin, and Sei Kwang Hahn, Effect of Osteoconductive Hyaluronate Hydrogels on Calvarial Bone Regeneration. Biomaterials Research 2014; 18: 8.

[51] Mark T. McClendon and Samuel I. Stupp, Tubular Hydrogels of Circumferentially Aligned Nanofibers to Encapsulate and Orient Vascular Cells. Biomaterials 2012; August ; 33(23): 5713–5722.

[52] Chandrasekhar R. Kothapalli, Patricia M. Taylor, Ryszard T. Smolenski, Magdi H. Yacoub, and Anand Ramamurthi, Transforming Growth Factor Beta 1 and Hyaluronan Oligomers Synergistically Enhance Elastin Matrix Regeneration by Vascular Smooth Muscle Cells. Tissue Engineering: Part A, 2009; Volume 15, Number 3.

DOI: https://doi.org/10.1089/ten.tea.2008.0040

[53] Rodríguez-castelán, Julia, Margarita Martínez-gómez, Francisco Castelán, and Estela Cuevas, Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of Endocrinology 2015; 19–21.

DOI: https://doi.org/10.1155/2015/917806

[54] Ellis, Cara E, Branka Vulesevic, Erik Suuronen, Telford Yeung, Karen Seeberger, and Gregory S Korbutt, Bioengineering a Highly Vascularized Matrix for the Ectopic Transplantation of Islets. Islets 2013; 5: 5, 216–225.

[55] Phelps, Edward A, Kellie L Templeman, and Veterans Affairs, Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization. Drug Deliv Transl Res 2015; April ; 5(2): 125–136.

[56] Chen, Wei-sheng, Zhiyi Cao, Satoshi Sugaya, Maria J Lopez, Victor G Sendra, Nora Laver, and others, Pathological Lymphangiogenesis Is Modulated by Galectin-8-Dependent Crosstalk between podoplanin and integrin-associated VEGFR-3. Nature Communications 2016; 7: 1–17.

DOI: https://doi.org/10.1038/ncomms11302

[57] Fiaschi-taesch, Nathalie M, Dora M Berman, Brian M Sicari, and Karen K Takane, Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets. Diabetes 2008; 57.

DOI: https://doi.org/10.2337/db08-1085

[58] Song, W Q, D Z Fu, Y Cheng, and Y F Liu, Influence of Adenosine on Preservation of Porcine Pancreas in Islet Transplantation. Genetics and Molecular Research 2015; 14: 18293–301.

DOI: https://doi.org/10.4238/2015.december.23.17

[59] Mohiuddin, Muhammad M, Avneesh K Singh, Philip C Corcoran, Marvin L Thomas Iii, Tannia Clark, Billeta G Lewis, and others, Chimeric 2C10R4 Anti-CD40 Antibody Therapy Is Critical for Long-Term Survival of GTKO. hCD46. hTBM Pig-to-Primate Cardiac Xenograft. Nature Communications 2016; 7: 1–10.

[60] Eike Kleinert, Martin C. Langenmayer, Bruno Reichart, Jana Kindermann, Barbara Griemert, Andreas Blutke, Kerstin Troidl, Tanja Mayr, Tobias Grantzow, Fatih Noyan, Jan-Michael Abicht, Silvia Fischer, Klaus T. Preissner, Ruediger Wanke, Elisabeth Deindl, Sonja Guethoff, Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. Journal of the American Heart Association 2016; 1–14.

[61] Morteza Abouzaripour, Iraj Ragerdi Kashani , Parichehr Pasbakhsh, and Nader Atlasy, Intravenous Transplantation of Very Small Embryonic Like Stem Cells in Treatment of Diabetes Mellitus. Avicenna J Med Biotech 2015; 7(1): 22-31.

[62] Deepa Bhartiya and Hiren Patel, Very small embryonic-like stem cells are involved in pancreatic regeneration and their dysfunction with age may lead to diabetes and cancer. Stem Cell Research & Therapy 2015; 6: 96.

[63] Juliana Navarro Ueda Yaochite, Carolina Caliari-Oliveira, Lucas Eduardo Botelho de Souza, Lourenço Sbragia Neto, Patrícia Vianna Bonini Palma, Dimas Tadeu Covas, Kelen Cristina Ribeiro Malmegrim, Julio César Voltarelli and Eduardo Antônio Donadi, Therapeutic efficacy and biodistribution of allogeneic mesenchymal stem cells delivered by intrasplenic and intrapancreatic routes in streptozotocin-induced diabetic mice. Stem Cell Research & Therapy 2015; 6: 31.

[64] M. E. Carlson, M. J. Conboy, M. Hsu, L. Barchas, J. Jeong, A. Agrawal, A. J. Mikels, D. V Schaffer, and I. M. Conboy, Relative roles of TGF- b 1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell 2009; No. 8 August: p.676.

DOI: https://doi.org/10.1111/j.1474-9726.2009.00517.x

[65] Song SY, Jung JE, Jeon YR, Tark KC, Lew DH, Determination of adipose-derived stem cell application on photo-aged fibroblasts, based on paracrine function. Cytotherapy 2011; Mar: 13(3): 378-84.

DOI: https://doi.org/10.3109/14653249.2010.530650

[66] S. A. Villeda, J. Luo, K. I. Mosher, B. Zou, M. Britschgi, T. M. Stan, N. Fainberg, Z. Ding, A. Eggel, M. Kurt, E. Czirr, J. Park, S. Couillard-després, L. Aigner, E. R. Peskind, J. A. Kaye, J. F. Quinn, and D. R. Galasko, The aging systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2012; vol. 477, no. 7362, p.90.

[67] Ionel Sandovici, Constanze M. Hammerle, Wendy N. Cooper, Noel H. Smith, Jane L. Tarry-Adkins, Benjamin J. Dunmore, Julien Bauer, Simon R. Andrews , Giles S. H. Yeo, Susan E. Ozanne, Miguel Constância, Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Diabetologia 2016; 59: 502–511.

DOI: https://doi.org/10.1007/s00125-015-3837-8

[68] Masako Imaoka, Toshimasa Jindo, and Wataru Takasaki, The Process and Development Mechanism of Age-related Fibrosis in the Pancreatic Islets of Sprague-Dawley Rats: Immunohistochemical Detection of Myofibroblasts and Suppression Effect by Estrogen Treatment. J Toxicol Pathol 2013; 26: 1–10.

[69] Salpeter SJ, Khalaileh A, Weinberg-corem N, Ziv O, Glaser B, Systemic Regulation of the Age-Related Decline of Pancreatic β -Cell Replication. Diabetes 2013; 62(August): 2843– 8.

[70] Medina A, Yamada S, Hara A, Hamamoto K, Kojima I. Involvement of the parasympathetic nervous system in the initiation of regeneration of pancreatic β-cells. Endocrine Journal 2013; 60(5): 687–96.

[71] M. M. Feng, Y. Xiang, S. Wang, and W. Lu, An autocrine γ-aminobutyric acid signaling system exists in pancreatic β -cell progenitors of fetal and postnatal mice. International Journal of Physiology, Pathophysiology and Pharmacology 2013; vol. 5, no. 2, p.91.

[72] Biankin A V, Waddell N, Kassahn KS et al., Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. NIH Public Access pathway genes 2012; 491(7424): 399–405.

DOI: https://doi.org/10.3410/f.717961686.793464443

[73] B. S. Pourcain, R. A. M. Cents, A. J. O. Whitehouse et al., Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature communications 2014; p.1–9.

[74] T. A. Evans, C. Santiago, E. Arbeille, and G. J. Bashaw, Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons. eLife 2015; p.1–26.

DOI: https://doi.org/10.7554/elife.08407

[75] G. Harburg, J. Compton, W. Liu, N. Iwai, S. Zada, R. Marlow, P. Strickland, Y. A. Zeng, and L. Hinck, SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling. Stem Cell Reports 2014; vol. 3, no. 3, p.385–393.

DOI: https://doi.org/10.1016/j.stemcr.2014.07.007

[76] H. A. N. Al-wadei, M. H. Al-wadei, M. F. Ullah, and H. M. Schuller, Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In-Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice. PLos ONE 2012; vol. 7, no. 8, pp: 1–11.

[77] Chen, Yi-ju, Stacy R Finkbeiner, Daniel Weinblatt, Matthew J Emmett, Feven Tameire, Maryam Yousefi, Chenghua Yang, et al. De Novo Formation of Insulin-Producing Neo - β Cell Islets, from Intestinal Crypts. Cell Reports 2013; no. 6: 1046–58. doi: 10. 1016/j. celrep. 2014. 02. 013.

[78] R. D. Hickey, F. Galivo, J. Schug, M. A. Brehm, A. Haft, Y. Wang, E. Benedetti, G. Gu, M. A. Magnuson, L. D. Shultz, E. Lagasse, D. L. Greiner, K. H. Kaestner, and M. Grompe, Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Research 2013; vol. 11, no. 1, p.503.

DOI: https://doi.org/10.1016/j.scr.2013.02.005

[1] Poitout, Vincent, and R Paul Robertson, Glucolipotoxicity : Fuel excess and β -cell dysfunction. Endocrine Reviews 2008; 29: 351–66. 10. 1210/er. 2007-0023.

DOI: https://doi.org/10.1210/er.2007-0023

[2] S. Jitrapakdee, A. Wutthisathapornchai, J. C. Wallace, and M. J. MacDonald, Regulation of insulin secretion: role of mitochondrial signaling. Diabetologia 2010; 53, 1019–32. 10. 1007/s00125-010-1685-0.

DOI: https://doi.org/10.1007/s00125-010-1685-0

[3] Jingbo Pi, Qiang Zhang, Jingqi Fu, Courtney G. Woods, Yongyong Hou, Barbara E Corkey, Sheila Collins, and Melvin E. Andersen, ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicology and Applied Pharmacology 2011; (244), 77–83. 10. 1016/j. taap. 2009. 05. 025.

DOI: https://doi.org/10.1016/j.taap.2009.05.025

[6] Chand S, A J Mcknight, S Shabir, W Chan, J A Mccaughan, A P Maxwell, and others, Analysis of Single Nucleotide Polymorphisms Implicate mTOR Signalling in the Development of New-Onset Diabetes after Transplantation. BBACLI 2016; 5: 41–45 . 10. 1016/j. bbacli. 2015. 12. 004.

DOI: https://doi.org/10.1016/j.bbacli.2015.12.004

[7] Bijkerk Roel, Pieter Van Der Pol, and Meriem Khairoun, Simultaneous Pancreas – Kidney Transplantation in Patients with Type 1 Diabetes Reverses Elevated MBL Levels in Association with MBL2 Genotype and VEGF Expression. Diabetologia 2016; 853–58 . 10. 1007/s00125-015-3858-3.

DOI: https://doi.org/10.1007/s00125-015-3858-3

[8] Nicholls Susan, Ricardo Pong-wong, Louisa Mitchard, Ross Harley, Alan Archibald, Andrew Dick, and others, Genome-Wide Analysis in Swine Associates Corneal Graft Rejection with Donor-Recipient Mismatches in Three Novel Histocompatibility Regions and One Locus Homologous to the Mouse H-3 Locus. PLos ONE 2016; 1–12 . 10. 1371/journal. pone. 0152155.

DOI: https://doi.org/10.1371/journal.pone.0152155

[9] Torren Cornelis R Van Der, Arnaud Zaldumbide, Dave L Roelen, Gaby Duinkerken, Simone H Brand-schaaf, Mark Peakman, and others, Innate and Adaptive Immunity to Human Beta Cell Lines : Implications for Beta Cell Therapy. Diabetologia 2016; 170–75. 10. 1007/s00125-015-3779-1.

DOI: https://doi.org/10.1007/s00125-015-3779-1

[10] Zhang Xiaohai, Nicole M Valenzuela, and Elaine F Reed, HLA class I antibody-mediated endothelial and smooth muscle cell activation. Curr Opin Organ Transplant 2012; August: 17(4). 10. 1097/MOT. 0b013e328355f1c2.

DOI: https://doi.org/10.1097/mot.0b013e328355f1c2

[11] Harper Ines G, Jason M Ali, Simon J F Harper, Menna R Clatworthy, Thomas M Conlon, Gavin J Pettigrew, and others, Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant Article Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant. Cell Reports 2016; 1–14. 10. 1016/j. celrep. 2016. 04. 009.

DOI: https://doi.org/10.1016/j.celrep.2016.04.009

[12] Wang Nan, Narendiran Rajasekaran, Tieying Hou, Claudia Macaubas, and D Mellins, Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation. PLos ONE 2015; 1–16. 10. 1371/journal. pone. 0128494.

DOI: https://doi.org/10.1371/journal.pone.0128494

[13] Rodríguez-castelán Julia, Margarita Martínez-gómez, Francisco Castelán, and Estela Cuevas, Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of Endocrinology 2015; 19–21. 10. 1155/2015/917806.

DOI: https://doi.org/10.1155/2015/917806

[14] Malihe-Sadat Poormasjedi-Meibod, Raza B. Jalili, Azadeh Hosseini-Tabatabaei, Ryan Hartwell, Aziz Ghahary, Immuno-Regulatory Function of Indoleamine 2 , 3 Dioxygenase through Modulation of Innate Immune Responses. PLos ONE 2013; Volume 8, Issue 8, e71044. 10. 1371/journal. pone. 0071044.

DOI: https://doi.org/10.1371/journal.pone.0071044

[16] Nagy Nadine, Gernot Kaber, Pamela Y Johnson, John A Gebe, Anton Preisinger, Ben A Falk, and others, Inhibition of Hyaluronan Synthesis Restores Immune Tolerance during Autoimmune Insulitis. The Journal of Clinical Investigation 2015; Volume 125 Number 10. 10. 1172/JCI79271DS1.

DOI: https://doi.org/10.1172/jci79271

[17] Bogdani Marika, Pamela Y Johnson, Susan Potter-perigo, Nadine Nagy, and Anthony J Day, Hyaluronan and Hyaluronan- Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis. Diabetes 2014; 63: 2727–2743 . 10. 2337/db13-1658.

DOI: https://doi.org/10.2337/db13-1658

[18] Bogdani Marika, Charmaine Simeonovic, Nadine Nagy, Pamela Y Johnson, K Chan, and Thomas N Wight, The Detection of Glycosaminoglycans in Pancreatic Islets and Lymphoid Tissues. Methods Mol Biol 2015; 1229: 413–430. 10. 1007/978-1-4939-1714-3_32.

DOI: https://doi.org/10.1007/978-1-4939-1714-3_32

[19] Paudel Suresh, Ioannis M Zacharioudakis, Fainareti N Zervou, Panayiotis D Ziakas, and Eleftherios Mylonakis, Prevalence of Clostridium difficile Infection among Solid Organ Transplant Recipients : A Meta-Analysis of Published Studies. PLos ONE 2015; 1–16 . 10. 1371/journal. pone. 0124483.

DOI: https://doi.org/10.1371/journal.pone.0124483

[20] Kim Sung-Han, Hyun-jeong Lee, Sun-mi Kim, Joo Hee Jung, Sung Shin, Young Hoon Kim, and others, Diagnostic Usefulness of Cytomegalovirus ( CMV ) - Specific T Cell Immunity in Predicting CMV Infection after Kidney Transplantation : A Pilot Proof-of- Concept Study. Infect Chemother 2015; 47(2): 105-110. 10. 3947/ic. 2015. 47. 2. 105.

DOI: https://doi.org/10.3947/ic.2015.47.2.105

[21] Sue Paul K, Nora Pisanic, Christopher D Heaney, Michael Forman, Alexandra Valsamakis, Annette M Jackson, and others, Hepatitis E Virus Infection Among Solid Organ Transplant Recipients at a North American Transplant Center. Open Forum Infectious Diseases 2012; 1–8. 10. 1093/ofid/ofw006.

DOI: https://doi.org/10.1093/ofid/ofw006

[22] Chedid Marcio F, Leandro A Scaffaro, Aljamir D Chedid, Antonio C Maciel, Carlos Thadeu S Cerski, Matheus J Reis, and others, Transarterial Embolization and Percutaneous Ethanol Injection as an Effective Bridge Therapy before Liver Transplantation for Hepatitis C-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice 2016; Article ID 9420274, 5 pages. 10. 1155/2016/9420274.

DOI: https://doi.org/10.1155/2016/9420274

[23] Saab Sammy, Justin Rheem, Melissa Jimenez, Sherona Bau, Gina Choi, Francisco Durazo, and others, Curing Hepatitis C in liver transplant recipients is associated with changes in Immunosuppressant use. Journal of Clinical and Translational Hepatology 2016; 4: 32–38. 10. 14218/JCTH. 2016. 00001.

DOI: https://doi.org/10.14218/jcth.2016.00070

[24] Alan D. Agulnick, Dana M. Ambruzs, Mark A. Moorman, Anindita Bhoumik, Rosemary M. Cesario, Janice K. Payne, Jonathan R. Kelly, Carl Haakmeester, Robert Srijemac, Alistair Z. Wilson, Justin Kerr, Mauro A. Frazier, Evert J. Kroon, Kevin A. D'amour, Tissue Engineering and Regenerative Medicine, Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo. Stem Cells Translational Medicine 2015; 4: 1214–1222. 10. 1007/s00125-013-2955-4.

DOI: https://doi.org/10.5966/sctm.2015-0079

[25] Pepper Andrew R, Rena Pawlick, Boris Gala-lopez, Amanda Macgillivary, Delfina M Mazzuca, David J G White, and others, Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device. Transplantation 2015; 99: 2294–2300. 10. 1097/TP. 0000000000000864.

DOI: https://doi.org/10.1097/tp.0000000000000864

[26] Yap Woon Teck, Xiaomin Zhang, Zachary G Bannon, Dixon B Kaufman, William L Lowe, and Lonnie D Shea, Collagen IV-Modified Scaffolds Improve Islet Survival and Function and Reduce Time to Euglycemia. Tissue Engineering: Part A 2013; Volume 19, Numbers 21 and 22. 10. 1089/ten. tea. 2013. 0033.

DOI: https://doi.org/10.1089/ten.tea.2013.0033

[27] McBane Joanne E, Branka Vulesevic, Donna T Padavan, Kimberly A Mcewan, S Gregory, and Erik J Suuronen, Evaluation of a Collagen-Chitosan Hydrogel for Potential Use as a Pro-Angiogenic Site for Islet Transplantation. PLos ONE 2013; 8: 1–15 . 10. 1371/journal. pone. 0077538.

DOI: https://doi.org/10.1371/journal.pone.0077538

[28] Ehrhart Friederike, Esther Mettler, Thomas Böse, Matthias Max Weber, and Julio Alberto Vásquez, Biocompatible Coating of Encapsulated Cells Using Ionotropic Gelation. PLos ONE 2013; 8: 1–9. 10. 1371/journal. pone. 0073498.

DOI: https://doi.org/10.1371/journal.pone.0073498

[29] Kuehn Carina, Jonathan R T Lakey, Morgan W Lamb, and Patrick Vermette, Young Porcine Endocrine Pancreatic Islets Cultured in Fibrin Show Improved Resistance toward Hydrogen Peroxide. Islets 2013; 207–15 10. 4161/isl. 26989.

DOI: https://doi.org/10.4161/isl.26989

[30] Guerreiro Luiz Henrique, Mariana F A N Guterres, Bruno Melo-ferreira, Luiza C S Erthal, Silva Rosa, Daniela Lourenço, and others, Preparation and Characterization of PEGylated Amylin. AAPS Pharm. SciTech 2013; Vol. 14, No. 3. 10. 1208/s12249-013-9987-4.

DOI: https://doi.org/10.1208/s12249-013-9987-4

[31] Yamashita Shingo, Kazuo Ohashi, Rie Utoh, Teruo Okano, and Masakazu Yamamoto, Human Laminin Isotype Coating for Creating Islet Cell Sheets. Cell Medicine 2015; 8: 39–46.

DOI: https://doi.org/10.3727/215517915x689029

[32] Willenberg Bradley J, Jose Oca-cossio, Yunqing Cai, Alicia R Brown, William L Clapp, Dale R Abrahamson, and others, Repurposed Biological Scaffolds : Kidney to Pancreas. Organogenesis 2015; 47–57. 10. 1080/15476278. 2015. 1067354.

DOI: https://doi.org/10.1080/15476278.2015.1067354

[33] Okawa Hiroko, Hiroki Kayashima, Jun-ichi Sasaki, Jiro Miura, Yuya Kamano, Yukihiro Kosaka, and others, Scaffold-Free Fabrication of Osteoinductive Cellular Constructs Using Mouse Gingiva-Derived Induced Pluripotent Stem Cells. Stem Cells International 2016; Article ID 6240794, 11 pages. 10. 1155/2016/6240794.

DOI: https://doi.org/10.1155/2016/6240794

[34] Sayed-Hadi Mirmalek-Sani, Giuseppe Orlando, John McQuilling, Rajesh Pareta, David Mack, Marcus Salvatori, Alan C Farney, Robert J Stratta, Anthony Atala, Emmanuel C Opara, and Shay Soker, Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials 2013; July; 34(22): 5488–5495. 10. 1016/j. biomaterials. 2013. 03. 054.

DOI: https://doi.org/10.1016/j.biomaterials.2013.03.054

[35] Johansson Ulrika, Massimiliano Ria, Å Karin, and Nancy Dekki Shalaly, Pancreatic Islet Survival and Engraftment Is Promoted by Culture on Functionalized Spider Silk Matrices. PLos ONE 2015; 1–21. 10. 1371/journal. pone. 0130169.

DOI: https://doi.org/10.1371/journal.pone.0130169

[36] Wu Di, Jian Wan, Yan Huang, Yibing Guo, Tianxin Xu, Mingyan Zhu, and others, 3D Culture of MIN-6 Cells on Decellularized Pancreatic Scaffold : In Vitro and In Vivo Study. BioMed Research International 2015; Article ID 432645, 8 pages. 10. 1155/2015/432645.

DOI: https://doi.org/10.1155/2015/432645

[38] Cavallo J A, S C Greco, J Liu, M M Frisella, C R Deeken, and B D Matthews, Remodeling characteristics and biomechanical properties of a crosslinked versus a non-crosslinked porcine dermis scaffolds in a porcine model of ventral hernia repair. Hernia 2015; April ; 19(2): 207–218. 10. 1007/s10029-013-1070-2.

DOI: https://doi.org/10.1007/s10029-013-1070-2

[40] Saeromi Jeong, Eun Jung Yoon, Hong Gook Lim, Si Chan Sung, and Yong Jin Kim, The Effect of Space Fillers in the Cross-Linking Processes of Bioprosthesis. BioResearch Open Access 2013; Vol : 2, 2. 10. 1089/biores. 2012. 0289.

DOI: https://doi.org/10.1089/biores.2012.0289

[42] Jiang T, Ren XJ, Tang JL, Yin H, Wang KJ, Zhou CL, Preparation and characterization of Genipin-crosslinked rat acellular spinal cord scaffolds. Mater Sci Eng C Mater Biol Appl 2013; Aug 1; 33(6): 3514-21. 10. 1016/j. msec. 2013. 04. 046.

DOI: https://doi.org/10.1016/j.msec.2013.04.046

[44] Wang Yujia, Ji Bao, Xiujuan Wu, Qiong Wu, Yi Li, Yongjie Zhou, and others, Genipin Crosslinking Reduced the Immunogenicity of Xenogeneic Decellularized Porcine Whole- Liver Matrices through Regulation of Immune Cell Proliferation and Polarization. Scientific Reports 2016; 1–16 . 10. 1038/srep24779.

DOI: https://doi.org/10.1038/srep24779

[45] Andreas M. Nyström and Karen L. Wooley, Thiol-functionalized shell crosslinked knedel-like (SCK) nanoparticles: A versatile entry for their conjugation with biomacromolecules. Tetrahedron 2008; September 1; 64(36): 8543–8552. 10. 1016/j. tet. 2008. 04. 104.

DOI: https://doi.org/10.1016/j.tet.2008.04.104

[46] M. El-Sherbiny and H. D. C. Smyth, Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I)Self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres. Int J Pharm 2010; August 16; 395. 10. 1016/j. ijpharm. 2010. 05. 032.

DOI: https://doi.org/10.1016/j.ijpharm.2010.05.032

[47] Tripathi Rahul, and Brahmeshwar Mishra, Development and Evaluation of Sodium Alginate – Polyacrylamide Graft – Co-Polymer- Based Stomach Targeted Hydrogels of Famotidine . AAPS 2012; 13. 10. 1208/s12249-012-9824-1.

DOI: https://doi.org/10.1208/s12249-012-9824-1

[48] Tania Betancourt, Juan Pardo, Ken Soo, and Nicholas A. Peppas, Characterization of pH-Responsive Hydrogels of Poly(Itaconic acid-g-Ethylene Glycol) Prepared by UV-Initiated Free Radical Polymerization as Biomaterials for Oral Delivery of Bioactive Agents. J Biomed Mater Res A 2010; April ; 93(1): 175–188. 10. 1002/jbm. a. 32510.

DOI: https://doi.org/10.1002/jbm.a.32510

[49] Wang Qinmei, and Qiong Wang, Hydrogels Containing Conductive Polymer Nanoparticles for Biomedical Applications. International Journal of Nanomedicine 2016; 11: 131–145. 10. 2147/IJN. S94777.

DOI: https://doi.org/10.2147/ijn.s94777

[50] Yeom Junseok, Byung Woo Hwang, Dong Jun Yang, Hong-in Shin, and Sei Kwang Hahn, Effect of Osteoconductive Hyaluronate Hydrogels on Calvarial Bone Regeneration. Biomaterials Research 2014; 18: 8. 10. 1186/2055-7124-18-8.

DOI: https://doi.org/10.1186/2055-7124-18-8

[51] Mark T. McClendon and Samuel I. Stupp, Tubular Hydrogels of Circumferentially Aligned Nanofibers to Encapsulate and Orient Vascular Cells. Biomaterials 2012; August ; 33(23): 5713–5722. 10. 1016/j. biomaterials. 2012. 04. 040.

DOI: https://doi.org/10.1016/j.biomaterials.2012.04.040

[52] Chandrasekhar R. Kothapalli, Patricia M. Taylor, Ryszard T. Smolenski, Magdi H. Yacoub, and Anand Ramamurthi, Transforming Growth Factor Beta 1 and Hyaluronan Oligomers Synergistically Enhance Elastin Matrix Regeneration by Vascular Smooth Muscle Cells. Tissue Engineering: Part A, 2009; Volume 15, Number 3. 10. 1089/ten. tea. 2008. 0040.

DOI: https://doi.org/10.1089/ten.tea.2008.0040

[53] Rodríguez-castelán, Julia, Margarita Martínez-gómez, Francisco Castelán, and Estela Cuevas, Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of Endocrinology 2015; 19–21. 10. 1155/2015/917806.

DOI: https://doi.org/10.1155/2015/917806

[54] Ellis, Cara E, Branka Vulesevic, Erik Suuronen, Telford Yeung, Karen Seeberger, and Gregory S Korbutt, Bioengineering a Highly Vascularized Matrix for the Ectopic Transplantation of Islets. Islets 2013; 5: 5, 216–225. 10. 4161/isl. 27175.

DOI: https://doi.org/10.4161/isl.27175

[55] Phelps, Edward A, Kellie L Templeman, and Veterans Affairs, Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization. Drug Deliv Transl Res 2015; April ; 5(2): 125–136. 10. 1007/s13346-013-0142-2.

DOI: https://doi.org/10.1007/s13346-013-0142-2

[56] Chen, Wei-sheng, Zhiyi Cao, Satoshi Sugaya, Maria J Lopez, Victor G Sendra, Nora Laver, and others, Pathological Lymphangiogenesis Is Modulated by Galectin-8-Dependent Crosstalk between podoplanin and integrin-associated VEGFR-3. Nature Communications 2016; 7: 1–17 . 10. 1038/ncomms11302.

DOI: https://doi.org/10.1038/ncomms11302

[57] Fiaschi-taesch, Nathalie M, Dora M Berman, Brian M Sicari, and Karen K Takane, Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets. Diabetes 2008; 57. 10. 2337/db08-1085.

DOI: https://doi.org/10.2337/db08-1085

[58] Song, W Q, D Z Fu, Y Cheng, and Y F Liu, Influence of Adenosine on Preservation of Porcine Pancreas in Islet Transplantation. Genetics and Molecular Research 2015; 14: 18293–301. 10. 4238/(2015).

DOI: https://doi.org/10.4238/2015.december.23.17

[59] Mohiuddin, Muhammad M, Avneesh K Singh, Philip C Corcoran, Marvin L Thomas Iii, Tannia Clark, Billeta G Lewis, and others, Chimeric 2C10R4 Anti-CD40 Antibody Therapy Is Critical for Long-Term Survival of GTKO. hCD46. hTBM Pig-to-Primate Cardiac Xenograft. Nature Communications 2016; 7: 1–10 . 10. 1038/ncomms11138.

DOI: https://doi.org/10.1038/ncomms11138

[60] Eike Kleinert, Martin C. Langenmayer, Bruno Reichart, Jana Kindermann, Barbara Griemert, Andreas Blutke, Kerstin Troidl, Tanja Mayr, Tobias Grantzow, Fatih Noyan, Jan-Michael Abicht, Silvia Fischer, Klaus T. Preissner, Ruediger Wanke, Elisabeth Deindl, Sonja Guethoff, Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. Journal of the American Heart Association 2016; 1–14. 10. 1161/JAHA. 116. 003429.

DOI: https://doi.org/10.1111/xen.12083_24

[63] Juliana Navarro Ueda Yaochite, Carolina Caliari-Oliveira, Lucas Eduardo Botelho de Souza, Lourenço Sbragia Neto, Patrícia Vianna Bonini Palma, Dimas Tadeu Covas, Kelen Cristina Ribeiro Malmegrim, Julio César Voltarelli and Eduardo Antônio Donadi, Therapeutic efficacy and biodistribution of allogeneic mesenchymal stem cells delivered by intrasplenic and intrapancreatic routes in streptozotocin-induced diabetic mice. Stem Cell Research & Therapy 2015; 6: 31. 10. 1186/s13287-015-0017-1.

DOI: https://doi.org/10.1186/s13287-015-0017-1

[67] Ionel Sandovici, Constanze M. Hammerle, Wendy N. Cooper, Noel H. Smith, Jane L. Tarry-Adkins, Benjamin J. Dunmore, Julien Bauer, Simon R. Andrews , Giles S. H. Yeo, Susan E. Ozanne, Miguel Constância, Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Diabetologia 2016; 59: 502–511. 10. 1007/s00125-015-3837-8.

DOI: https://doi.org/10.1007/s00125-015-3837-8

[68] Masako Imaoka, Toshimasa Jindo, and Wataru Takasaki, The Process and Development Mechanism of Age-related Fibrosis in the Pancreatic Islets of Sprague-Dawley Rats: Immunohistochemical Detection of Myofibroblasts and Suppression Effect by Estrogen Treatment. J Toxicol Pathol 2013; 26: 1–10. 10. 1293/tox. 26. 1.

DOI: https://doi.org/10.1293/tox.26.1

[69] Salpeter SJ, Khalaileh A, Weinberg-corem N, Ziv O, Glaser B, Systemic Regulation of the Age-Related Decline of Pancreatic β -Cell Replication. Diabetes 2013; 62(August): 2843– 8. 10. 2337/db13-0160.

DOI: https://doi.org/10.2337/db13-er09

[76] H. A. N. Al-wadei, M. H. Al-wadei, M. F. Ullah, and H. M. Schuller, Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In-Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice. PLos ONE 2012; vol. 7, no. 8, pp: 1–11. 10. 1371/journal. pone. 0043376.

DOI: https://doi.org/10.1371/journal.pone.0043376

[77] Chen, Yi-ju, Stacy R Finkbeiner, Daniel Weinblatt, Matthew J Emmett, Feven Tameire, Maryam Yousefi, Chenghua Yang, et al. De Novo Formation of Insulin-Producing Neo - β Cell Islets, from Intestinal Crypts. Cell Reports 2013; no. 6: 1046–58. 10. 1016/j. celrep. 2014. 02. 013.

DOI: https://doi.org/10.1016/j.celrep.2014.02.013

[78] R. D. Hickey, F. Galivo, J. Schug, M. A. Brehm, A. Haft, Y. Wang, E. Benedetti, G. Gu, M. A. Magnuson, L. D. Shultz, E. Lagasse, D. L. Greiner, K. H. Kaestner, and M. Grompe, Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Research 2013; vol. 11, no. 1, p.503.

DOI: https://doi.org/10.1016/j.scr.2013.02.005
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