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Pharmacology and Ethnomedicine of the Genus <i>Astragalus</i>
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Pharmacology and Ethnomedicine of the Genus Astragalus

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Abstract:

The genus Astragalus, consisting of about 3000 species, is a valuable source of herbal drugs. The review article comprises scientific data concerning morphological, distribution and phytochemical characters of the genus. Polysaccharides, saponins, and flavonoids are considered main active principles. Astragalus spp. have long been used as medicinal plants in folk medicine as cardiovascular, antihypertensive, diuretic, choleretic, as well as antimicrobial and antiviral agents. The plants of the genus exhibit a broad spectrum of pharmacological effects, among which major include diuretic, anti-inflammatory, bactericidal, hypotensive, and sedative ones. The review focuses on uses of about 30 Astragalus species in official medicine and ethnomedicine and their pharmacological action.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 3)
Pages:
46-53
DOI:
https://doi.org/10.18052/www.scipress.com/IJPPE.3.46
Citation:
R. Lysiuk and R. Darmohray, "Pharmacology and Ethnomedicine of the Genus Astragalus", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 3, pp. 46-53, 2016
Online since:
June 2016
Authors:
Roman Lysiuk, Roman Darmohray
Keywords:
Anti-Inflammatory, Bactericidal, Diuretic, Ethnomedicine, Fabaceae, Folk Medicine Remedies, Genus Astragalus L., Official Species, Pharmacology
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RIS, BibTeX, Text
Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

[1] A. Shojaii, et al, Evaluation of Anti-inflammatory and Analgesic Activity of the Extract and Fractions of Astragalus hamosus in Animal Models, Iranian Journal of Pharmaceutical Research. 14 (1) (2015) 263-269.

[2] V.N. Belous, Astragalus spp. and their significance for Pre-Caucasian flora, Ph.D. dissertation, Stavropol State University, Stavropol, Russia, 2005 (in Russ. ).

[3] R. N. Chopra, I. C. Chopra, B. S. Varma, Supplement to Glossary of Indian Medicinal Plants, Publications and Information Directorate, New Delhi, India, (1974).

[4] D.T. Chu, W.L. Wong, G.M. Mavligit, Immunotherapy with Chinese medicinal herbs I. Immune restoration of local xenogeneic graft-versus-host reactions in cancer patients by fractionated Astragalus membranaceus in vitro, Journal of clinical laboratory immunology. 25 (1988).

[5] M. Dimitrov, et al, Preparation of hydrogel tablets based on polyethylene oxide with standardized dry extract of Astragalus corniculatus Bieb. (Fabaceae), Pharma News. 32 (2003) 3-17.

[6] I. Dineva, et al, In vitro antineoplastic activity of some cytoreductive drugs versus new compounds of plant origin, International Journal of Current Chemistry. 1(4) (2010) 281-290.

[7] Ev. Ermolaev, Research on conservation possibilities for Astragalus dasyanthus Pall. in the Republic of Moldova, CBM Master Theses, No. 33, Swedish Biodiversity Centre, Uppsala, Sweden, (2007).

[8] European Pharmacopoeia, 8. 0. ed., Council of Europe, European Directorate for the Quality of Medicines, Strasbourg, France, (2013).

[9] G. Carmine, L. De Simon, S. Santoro, Ethnobotanical Study of the Sannio Area, Campania, Southern Italy, Ethnobotany Research and Applications. 6 (2008) 255-317.

DOI: https://doi.org/10.17348/era.6.0.255-317

[10] A. Hakim, A. Tajuddin, J. Nasreen, Evaluation of anti-inflammatory activity of the pods of Iklil-ul-Malik (Astragalus hamosus Linn. ), Indian J. Natural Products and Resources. 1 (2010) 34-37.

[11] S. Ivancheva, M. Nikolova, R. Tsvetkova, Pharmacological activities and biologically active compounds of Bulgarian medicinal plants, in: F. Imperato (Ed. ), Phytochemistry: Advances in Research, Research Signpost, Trivandrum, Kerala, India, 2006, pp.87-103.

[12] E. P. Kemertelidze, Biologically Active Compounds and Medical Preparations from Some Plants Growing in Georgia, Chemistry for Sustainable Development. 16 (2008) 75–83.

[13] A. Khoron'ko, V. Glyzin, Flavonoids of Astragalus dasyanthus, Khimiya Prirodnykh Soedinenii. 3 (1973) 431. (in Russ. ).

[14] M. Kondeva-Burdina, et al, Protective effects of extract from Astragalus glycyphylloides on carbon tetrachloride-induced toxicity in isolated hepatocytes, Biotechnology and Biotechnological Equipment. 27(3) (2013) 3866- 3869.

DOI: https://doi.org/10.5504/bbeq.2013.0023

[15] I. Krasteva, et al, Phytochemical analysis of ethyl acetate extract from Astragalus corniculatus Bieb. and brain anthihypoxic activity, Acta Pharmaceutica. 54(2) (2004) 151-156.

[16] I. Krasteva, et al, Antiproliferative effects of a flavonoid and saponins from Astragalus hamosus against human tumor cell lines, Phcog Mag. 4(16) (2008) 269-272.

[17] I. Krasteva, et al, Phytochemical analysis and in vitro cytotoxic activity of volatiles from Astragalus corniculatus, Natural Product Research. 22(11) (2008) 969-974.

DOI: https://doi.org/10.1080/14786410701650287

[18] I.N. Krasteva, R.A. Toshkova, S.D. Nikolov, Protective Effect of Astragalus corniculatus Saponins against Myeloid Graffi Tumor in Hamsters, Phytotherapy Research. 18(3) (2004) 255-257.

DOI: https://doi.org/10.1002/ptr.1277

[19] A. N. Kudrin, et al, Effect of atenolol, dibunol, peroxidase and Astragalus dasynthus on the morphometric parameters of myocardial infarction, Farmakol. Toksikol. 50 (1987) 47-51 (in Russ. ).

[20] I.E. Lobanova, Phytochemical characteristics of Astragalus glycyphyllos (Fabaceae), J. Plant world of the Asian Russia. 1 (2011) 87–90. (in Russ. ).

[21] S. Marinova, et al, Immunomodulating effect of triterpenoid saponins from Astragalus onobrychis L., Farmacia (Sofia). 6 (1994) 38–41.

[22] M. Mitcheva, M. Kondeva-Burdina, I. Krasteva, S. Nikolov, Protective effect of purified mixture from Astragalus corniculatus on toxicity models in vitro, in: S. Tonev, K. Kanev, Ch. Dishovsky (Eds. ), Medical management of chemical and biological casualties, Publishing House Irita, Military Medical Academy, Sofia, 2009, pp.239-251.

DOI: https://doi.org/10.1080/13880200802367247

[23] M. Mitcheva, et al, Effect of purified saponins' mixture from Astragalus corniculatus on toxicity models in isolated rat hepatocytes, Pharmaceutical Biology. 46(12) (2008) 866-870.

DOI: https://doi.org/10.1080/13880200802367247

[24] G. Momekov, et al, Cytotoxic activity of volatiles from four Astragalus species, Dokladi Na. B. Lgarskata Akademiâ Na Naukite. 60 (2007) 1023-1026.

[25] L. Pistelli, Secondary Metabolites of Genus Astragalus: Structure and Biological Activity, in: Atta-Ur-Rahman (Ed. ), Studies in Natural Products Chemistry, Elsevier Science B.V., Vol. 27, 2002, pp.443-545.

DOI: https://doi.org/10.1016/s1572-5995(02)80043-6

[26] The genus Astragalus L., in: Sokolov P.D. (Ed. ), Plant resources of USSR: Flowering plants, chemical content, uses (Hydrangeaceae – Haloragaceae), Nauka, Leningrad, USSR, 1987, p.109–125 (in Russ. ).

[27] L.J. Rios, P.G. Waterman, A review of the pharmacology and toxicology of Astragalus, Phytother Res. 11(6). (1997) 411-418.

[28] K.N. Safar, S.K. Osaloo, A.A. Maassoumi, Re-assessment of subspecific taxa in Astragalus section Anthylloidei (Fabaceae) based on molecular evidence, Progress in Biological Sciences. 4(2) (2014) 219-234.

[29] R. Simeonova, et al, Antioxidant and hepatoprotective effects of aqueous-ethanolic extract from Astragalus glycyphylloides, International Journal of Pharma and Bio Sciences. 4(3) (2013) 179-186.

[30] R. Simeonova, et al, Effect of Astragalus corniculatus on enzymatic and nonenzymatic lipid peroxidation (LPO) in liver microsomes from spontaneously hypertensive rats (SHR) and normotensive rats (NTR), Phytomedicine. 17(5) (2010) 346-349.

DOI: https://doi.org/10.1016/j.phymed.2009.08.013

[31] N.P. Skakun, E.I. Blikhar, A.N. Oleĭnik, Use of Astragalus dasyanthus in lesions of the liver in patients with pulmonary tuberculosis, Vrachebnoe Delo. 6 (1998) 51-54 (in Russ. ).

[32] E. Souri, G. Amin, H. Farsam, Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts, Daru J. Pharm. Sci. 16 (2008) 83-87.

[33] K.I. Stepashkina, Astragalus and its application in clinical practice, The state medicinal publishing house, Kyiv, USSR, 1959 (in Russ. ).

[34] M. Tomoda, et al., Reticuloendothelial System-Activating Glycan from the Roots of Astragalus membranaceus, Phytochemistry. 31 (1992) 63–66.

DOI: https://doi.org/10.1016/0031-9422(91)83006-7

[35] R. A. Toshkova, et al, Influence of purified saponin mixture from Astragalus corniculatus Bieb. on phagocytic cells in Graffi tumor bearing hamsters, Journal of Ethnopharmacology. 109(3) (2007) 394-399.

DOI: https://doi.org/10.1016/j.jep.2006.08.006

[36] R.A. Toshkova, I.N. Krasteva, S.D. Nikolov, Immunorestoration and augmentation of mitogen lymphocyte response in Graffi tumor bearing hamsters by purified saponin mixture from Astragalus corniculatus, Phytomedicine. 15 (10) (2008) 876–881.

DOI: https://doi.org/10.1016/j.phymed.2007.11.026

[37] Verotta L., et al, Cycloartane and oleanane saponins from Egyptian Astragalus spp. as modulators of lymphocyte proliferation, Planta Med. – 68(11) (2002) 986-994.

DOI: https://doi.org/10.1055/s-2002-35654

[38] Vitcheva V., et al, Protective effects of a purified saponin mixture (PSM), isolated from Astragalus corniculatus Bieb., evaluated with in vivo hepatotoxicity models, Phytotherapy Research. 27(5) (2013) 731-736.

[39] Wassila Benchadi, et al, Secondary Metabolites of Astragalus cruciatus Link. and Their Chemotaxonomic Significance, Rec. Nat. Prod. 7 (2) (2013) 105-113.

[40] WHO Monographs on Selected Medicinal Plants, vol. 1, World Health Organization, Geneva, Switzerland, (1999).

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