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Anti-Inflammatory Activity of Chrozophora rottleri Extracts on Carrageenan-Induced Rat Paw Edema

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The present study was intended to evaluate Anti-inflammatory activity of C. rottleri extracts (Hydroalcoholic, Methanol, Ethyl acetate and Hexane). The Anti-inflammatory activity of C. rottleri extracts at doses of 125mg/kg, 250mg/kg and 500mg/kg using carrageenan induced rat paw edema model compared with standard drug (Indomethacin). The selected plant extracts significantly inhibited paw edema along with the standard drug Indomethacin. Of all extracts, methanol extract produced significant effect on reduction of increased paw thickness, hydro alcoholic and ethyl acetate extracts produced moderate percentage inhibition and hexane extract produced low level of percentage inhibition in reducing paw edema on carrageenan induced rats. In all extracts, methanol extract at a dose of 500mg/kg showed more percentage inhibition i.e . 53.47±2.19. From the results obtained during the study it is concluded that C. rottleri having the bioactive molecule responsible for Anti-inflammatory activity by individually or by combination of different bio-active compounds present in it. Further is necessary for isolation and characterization of bioactive molecules which are responsible for the selected plant biological activities.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 3)
M. R. Talluri et al., "Anti-Inflammatory Activity of Chrozophora rottleri Extracts on Carrageenan-Induced Rat Paw Edema", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 3, pp. 20-26, 2016
Online since:
Jun 2016

[1] Perez R.M.G. Anti-Inflammatory Activity of Compounds Isolated from Plants. The Scientific World. 1 (2001) 713-784.

DOI: 10.1100/tsw.2001.77

[2] Maruthappan V. and K. Sakthi Shree. In vitro and in vivo antioxidant activity of Phyllanthus reticulates, Drug Invention Today. 2(6) (2010) 303-307.

[3] Srinivasan, D., Nathan, S., Suresh, T., Perumalsamy, O. Antimicrobial activity of certain Indian medicinal plants used in folkloric medicine. J Ethnopharmacol. 74 (2001) 217-220.

DOI: 10.1016/s0378-8741(00)00345-7

[4] Handa, S.S., Sharma, A., Chakraborty, K.K., Natural products and plants as liver protecting drugs. Fitoterapia, 57 (1986) 307–351.

[5] Shah Biren N, Nayak B. S, Seth A. K, Jalalpure S. S, Patel K. N, Patel M.A. and Mishra A.D. Search for medicinal plants as a source of anti-inflammatory and anti-arthritic agents - A review. Phcog Mag, 2 (6) (2006).

[6] Larson RA. The antioxidants of higher plants, Phytochem, 27 (1998) 969-78.

[7] Tripathi YB, Chaurasia S, Tripathi E, Upadhyay A, Dubey GP. Bacopa monniera Linn. As an antioxidant, Mechanism of action. Ind J of Exp Biol. 34 (1996) 523-26.

[8] Woldesellassie Mequanint, Eyasu Makonnen, Kelbessa Urga. In vivo anti-inflammatory activities of leaf extracts of Ocimum lamiifolium in mice model. Journal of Ethnopharmacology. 134 (2011) 32–36.

DOI: 10.1016/j.jep.2010.11.051

[9] Ajay Kumar Meena and Rao M M., Folk herbal medicines used by the Meena community in Rajasthan. Asian Journal of Traditional Medicines. 5 (1) (2010) 19-31.

[10] Manandhar N. P. and Manandhar S. Plants and people of Nepal. Timber Press, Incorporated. (2002)150.

[11] Singh K. P, Achuta Nand Shukla and J. S. Singh. State-level inventory of invasive alien plants, their source regions and use potential. Current Science. 99(1) (2010) 10.

[12] Khare C.P. Indian Medicinal Plants, An Illustrated Dictionary. Springer, (2007).

[13] Sasinath Jha. Phytodiversity in Beeshazar Lake and Surrounding Landscape System. Our Nature, 5 (2007) 41-51.

DOI: 10.3126/on.v5i1.797

[14] Ganga Rao B, Y Venkateswara Rao, T Mallikarjuna Rao. Anti-bacterial Activity Different extracts of Chrozophora rotteleri. Inventi Rapid, Ethnopharmacology, 3 (2012) 1-3.

[15] Winter, Cara C.A., Risely, E.A., Nuss, G.W. Carrageenan-induced edema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med, 111 (1962) 544–547.

[16] Battu GR, Zeitlin IJ, Gray AI. Anti-inflammatory activity of adjuvant-induced arthritis in rats of octanordammarane triterpenes from resin extracts of Commiphora Kua. Br J Pharmacol, 133 (2000) 199.

[17] Cowan, M.M., Plants products antimicrobial agents. Clinical Microbiology Reviews. 14 (1999) 564–584.

[18] Alsarra, A.I., Ahmed, O.M., Alanazi, K.F., El Tahir, H.E.K., Alsheikh, M.A., Neau, H.S. Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-InducedGastric Ulceration in Rats. International Journal of Medical Sciences. 7 (2010).

DOI: 10.7150/ijms.7.232

[19] Tan, H.H., Ong, W.M.C., Lai, S.H., Chow, W.C., Nimesulide-induced hepato- toxicity and fatal hepatic failure. Singapore Medical Journal. 48 (2007) 582–585.

[20] Mazzanti, G., and Braghiroli, L., Analgesic anti-inflammatory action of Pfaffia paniculata (Martius) Kuntze. Phytotherapy Research. 8 (1994) 413–416.

DOI: 10.1002/ptr.2650080707

[21] Panthong, A., Supraditaporn,.W., Kanjanapothi, D., Taesotikul, T., Reutrakul, V., Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. J Ethnopharmacology. 110 (2007) 264–270.

DOI: 10.1016/j.jep.2006.09.018

[22] Lin, C. and Lin, W., Anti-inflammatory and hepatoprotective effects of Ventilago leiocarpa. Phytotherapy Research. 9 (1995) 11–15.

[23] Suba, V., Murugesan, T., Kumaravelrajan, R., Mandal, S.C., Saha, B.P., Antiinflammatory, analgesic and antiperoxidative efficacy of Barleria lupulina Lindl. extract. Phytotherapy Research. 19 (2005) 695–699.

DOI: 10.1002/ptr.1734

[24] Abdel-Sattar, E.A., A Pharmacognostical Study of Chrozophora plicata (Vahl. ) Growing in Egypt. MSc thesis, Faculty of Pharmacy, Cairo University, Cairo, Egypt, (1985).

[25] Agrawal, A. and Singh, J. Glycosides of two xanthones and A chromone from roots of Chrozophora prostrata. Phytochemistry. (2 (7)1988) 3692.

DOI: 10.1016/0031-9422(88)80803-3

[26] Hashim O.K., Abou-Zaid, M.M., Abdel-Galil, F.M. and Saleh, N.A.M. The flavonoids of Egyptian Chrozophora species. Biochem. Syst. Ecol. 18 (1990) 151–152.

DOI: 10.1016/0305-1978(90)90051-g
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