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IJPPE > Volume 3 > (+)-Spectaline, a Piperidine Alkaloid from Senna...
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(+)-Spectaline, a Piperidine Alkaloid from Senna spectabilis DC. Effective in Reducing the In Vitro Infection of Leishmania major

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Abstract:

Senna spectabilis is known to have antimicrobial, laxative, antiulcerogenic, analgesic, and anti-inflammatory properties in folk medicine. Piperidine alkaloids extracted from various parts of this plant have been shown to have anticonvulsant (iso-6-spectaline), antinociceptive [(-)-spectaline] and lipid peroxidation [(+)-3-O-feruloylcassine, (-)-spectaline and (-)-3-O-acetylspectaline] activities. In our study, the ethyl acetate extract from S. spectabilis exhibited antileishmanial activity via intracellular promastigote assay or leishmanicidal assay and was further fractionated by using bioassay-guided isolation approach. The antiprotozoal principle was isolated from the ethyl acetate portion through solvent fractionation and a few series of chromatographic processes. The isolated active compound 1 was identified as (+)-spectaline on the basis of its spectral analysis (MS, 1D & 2D NMR) with EC50 value of 0.063 ± 0.005 µM for antileishmanial activity and selectivity index of 3.76.

Info:

Periodical:
International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 3)
Pages:
1-8
DOI:
10.18052/www.scipress.com/IJPPE.3.1
Citation:
A. Amat Sain et al., "(+)-Spectaline, a Piperidine Alkaloid from Senna spectabilis DC. Effective in Reducing the In Vitro Infection of Leishmania major", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 3, pp. 1-8, 2016
Online since:
Jun 2016
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