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Histoarchitectural Changes in the Liver Following Lactational Lead Intoxication in Sprague Dawley Rats

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The present experiment was designed to study the histoarchitectural changes in the liver following lactational lead (Pb) intoxication in rats. A total of 12 adult female and 4 male rats were used in the experiment and 32 offspring for the analysis of lactational lead intoxication. The offspring were divided into four groups. Groups B, C and D were administered 10 mg/dL, 30 mg/dL and 70 mg/dL of lead acetate respectively, via drinking water for 21 days through the lactating mothers while group A was control. The livers of the pups were observed using histological methods. One-way ANOVA was used to analyze data, followed by Tukey post hoc test for multiple comparisons. The results from the analysis showed that the total body weight, body length and liver weights were only slightly altered in the Pb intoxicated groups. Using relative liver weights alone revealed some form of hepatomegaly among the experimental groups. The results revealed a dose-dependent increase in blood lead concentration. Histopathological evidences revealed moderate to severe histoarchitectural distortions along Pb concentration gradient. Lactational lead intoxication portends dose dependent histopathological changes in the liver of SD rats.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 16)
A. S. Odukoya et al., "Histoarchitectural Changes in the Liver Following Lactational Lead Intoxication in Sprague Dawley Rats", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 16, pp. 11-20, 2021
Online since:
February 2021

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