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The Comparative Effect of Hydro Alcoholic and Hydro Distillation Extracts of Melissa officinalis on Acne and Pimple

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One of the famous plants in family Lamiaceae is Melissa officinalis which is one of the important herbs for health and Medicine. Melisa contains Rosmarinic acid, flavonoids and phenolic. These components have tightening and rejuvenation effect on skin. Also, it has monoterpenes and di-terpenes which are antibacterial. Essential oil of Melisa forms a good complex with sebum, so it can decrease inflammation and acne pain 30 gr of dry leaves and stems of Melisa in 500 ml of distilled water were used for hydro-distillation. For hydro alcoholic extract, we used 150 gr of dry matter (leaves and stems) in 500 ml of ethyl alcohol at 25 °C for 10 days. Then, the alcoholic extract was diluted 5 times with water 20 persons were under experiment for 3 months. Extracts were sprayed on skin 3-5 times a day. The results showed that all the people treated got the best result of this treatment. After the application of the water extract of Melissa, we observed 75% of clients improved the skin pore, 65% of clients improved neurological problems and Acne infections and 92% recovery of hyper secretion of Sebaceous glands. We observed the same results with Hydro Alcoholic extracts. 75% recovery of clients with improved skin pore, 95% of clients with improved neurological problems and Acne infections and 90% recovery of hyper secretion of Sebaceous glands. The results showed that Melisa extract has value of applying on some skin problems.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 12)
G. Sabet Teymouri and M. Sabet Teimouri, "The Comparative Effect of Hydro Alcoholic and Hydro Distillation Extracts of Melissa officinalis on Acne and Pimple", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 12, pp. 35-43, 2019
Online since:
February 2019

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Cited By:

[1] D. Dimitris, T. Ekaterina-Michaela, K. Christina, S. Ioannis, S. Ioanna, L. Aggeliki, H. Sophia, R. Michael, S. Helen, "Melissa officinalis ssp. altissima extracts: A therapeutic approach targeting psoriasis in mice.", Journal of Ethnopharmacology, p. 112208, 2019


[2] P. Sitarek, T. Kowalczyk, J. Wieczfinska, A. Merecz-Sadowska, K. Górski, T. Śliwiński, E. Skała, "Plant Extracts as a Natural Source of Bioactive Compounds and Potential Remedy for the Treatment of Certain Skin Diseases", Current Pharmaceutical Design, Vol. 26, p. 2859, 2020