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International Journal of Pharmacology, Phytochemistry and Ethnomedicine
IJPPE Volume 1

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Faster Recovery after Exercise with Phytochemicals Aimed at Mitochondrial Energy Turnover - A Double Blind Randomized Placebo Control Study in College Female Soccer Players

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In order to replenish energy stores after exercise we developed a nutraceutical containing ingredients that precisely fuel the ATP generating mitochondria thus resulting in a faster recovery after workout.To test the working hypothesis 18 healthy female college soccer players (mean age 18) enrolled in a short but extreme workout on the treadmill for 12 min as demonstrated in their rise in lactic acid. The volunteers were given an energy drink containing Q10-H2 (ubiquinol), NADH (nicotinamide-adenine-dinucleotide-hydride or Q1), ribose, eleutherosides B & E, Vit B2 & B3, passion flower and Vit E over a period of one week. Following a washout of 4 weeks a similar looking and tasting placebo solution was given in a double blind randomized crossover design. Heart rate recovery rate and systolic blood pressure demonstrated a significant faster return to base line than after placebo within the first 1-5 minutes following exercise. In addition, ATP regeneration capacity in leucocytes following washout of sodiumazide, a specific inhibitor at the mitochondrial electron transport complex V, was statistically higher (p < 0.05) in subjects after verum.The composition consisting of mitochondrial active substances, results in a higher synthesis rate of ATP, which coincided with a faster heart rate recovery rate after workout.


International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 1)
E. Freye and H.P. Strobel, "Faster Recovery after Exercise with Phytochemicals Aimed at Mitochondrial Energy Turnover - A Double Blind Randomized Placebo Control Study in College Female Soccer Players", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 1, pp. 65-73, 2015
Online since:
December 2015

[1] Birkmayer, J., G ,D. and P. Vank (1996). Reduced coenzyme 1 (NADH) improves pyschomotoric and physical performance in athletes. White Paper Report. New York, Menuco Corp.

[2] Bowler, M. W., M. G. Montgomery, A. G. W. Leslie and J. E. Walker (2006). How azide inhibits ATP hydrolysis by the F-ATPases., PNAS 103: 8646-8649.

[3] Cole, C., E. H. Blackstone, F. J. Pashkow, C. E. Snader and M. S. Lauer (1999). Heart-rate recovery immediately after exercise as a predictor of mortality., N Engl J Med 342: 1351-1357.


[4] Dimkpa, U. (2009). Post-exercise heart rate recovery: an index of cardiovascular fitness., JEPonline 12: 19-22.

[5] Eaton, S., B. Middleton, H. Sherratt, M. Pourfarzam, P. Quant and K. Bartlett (2002). Control of Mitochondrial β-Oxidation at the Levels of [NAD+]/[NADH] and CoA Acylation., Adv Expert Med Biol 466: 145-154.


[6] Fang, J. N., A. Proksch and H. Wagner (1985). Immunlogically active polysaccharides of acanthopanax senticosus., Phytochemistry 11: 2619-2622.


[7] Farensworth, N. R., A. D. Kinghorn, D. D. Soejarto and D. P. Waller (1985).

[8] Fossilien, E. (2001). Mitochondrial medicine-molecular pathology of defective oxidative phosphorylation., Ann Clin Lab Sci 31: 25-76.

[9] Freye, E. and J. Gleske (2013). Siberian Ginseng Results in Beneficial Effects on Glucose Metabolism in Diabetes Type 2 Patients: A Double Blind Placebo-Controlled Study in Comparison to Panax Ginseng., Int J Clin Nutri 1: 11-17.

[10] Hosoe, K., M. Kitano, H. Kishida, H. Kubo, K. Fujii and M. Kitahara (2007).

[11] Jouven, X., J. P. Empana, S. P.J., M. Michel Desnos, D. Courbon and P. Ducimetière (2005). Heart-rate profile during exercise as a predictor of sudden death., N Engl J Med 352: 1951-(1958).


[12] KamMing, K. and Y. L. Hoi (2007). Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs- A Review., Chin Med 2: 1-10.


[13] Ko, K. M., T. Y. Leon, D. H. F. Mak, P. Y. Chiu, Y. Du and M. K. T. Poon (2006). A characteristic pharmacological action of 'Yang-invigorating' Chinese tonifying herbs: Enhancement of myocardial ATPgeneration capacity., Phytomedicine 13: 636-642.


[14] Korge, P. (1995). Factors limiting adenosine triphosphatase function during high intensity exercise. Thermodynamic and regulatory considerations., Sports Med 20: 215-225.


[15] McDonald, T., W. E. Hoffman, R. Berkowitz, F. Cunningham and B. Cooke (1999). Heart rate variability and plasma catecholamines in patients during opioid detoxification., J Neurosurg Anesthesiol 11: 195-199.


[16] Pedersen, D. J., S. J. Lessard, V. G. Coffey, C. E.G., A. M. Wootton, T. Ng, M. J. Watt and J. A. Hawley (2008).

[17] Pliml, W., T. von Arnim, A. Stablein, H. Hofmann, H. -G. Zimmer and E. Erdmann (1992). Effects of ribose on exercise-induced ischaemia in stable coronary artery disease., Lancet 340: 507 - 510.


[18] Segal, S. and F. J. T (1958). The metabolism of D-ribose in man., J Clinical Invest 37: 719 - 735.

[19] Sen, S., B. K. Kundu, H. C. -J. Wu, S. S. Hashmi, P. Guthrie, L. W. Locke, R. J. Roy, G. P. Matherne, S. S. Berr, M. Terwelp, B. Scott, S. Carranza, O. H. Frazier, D. K. Glover, W. H. Dillmann, M. J. Gambello, M. L. Entman and T. H. (2013).


[20] Shults, C. W., M. F. Bealc, D. Songa and D. Fontaine (2004). Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease., Expt Neurol 188: 491-394.


[21] Zimmer, H. -G. and J. Schad (1984). Ribose intervention in the cardiac pentose phosphate pathway is not species-specific., Science 223: 712 - 713.

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