Hepatoprotective Effect of Methanolic Leave Extracts of V. album on Paracetamol-Induced Laboratory Animals

Yusuf, L.; Oladunmoye, M.K.; Ogundare, A.O.

doi:10.18052/www.scipress.com/IJPPE.1.46

IJPPE > IJPPE Volume 1 > Hepatoprotective Effect of Methanolic Leave...

< Back to Volume

Hepatoprotective Effect of Methanolic Leave Extracts of V. album on Paracetamol-Induced Laboratory Animals

Full Text PDF

Abstract:

Hepatoprotective assay was carried out on laboratory animals in which paracetamol (oral dose,2 g/kg /body weight) was used to induce hepatotoxicity. The animals were orogastrically fed with the Viscum album (growing on cocoa and cola host trees) methanolic leave extracts. The activities of serum enzyme biomarkers showed no significant difference (P< 0.05) for V. album growing on cocoa (1000-5000mg/kg) but there were corresponding significant increase in the serum enzymes (P< 0.05) for V. album growing on cola at 4000 and 5000 mg/kg doses. Similarly, the photomicrograms of the animals’ vital organs (liver, stomach, small intestine and kidneys) studied revealed that V. album extract growing on cocoa was more hepatoprotective efficacious than that growing on cola tree on all the biochemical parameters that were screened for when compared with sylimarin (a standard heptoprotective drug).

Info:

Periodical:

International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 1)

Pages:

46-54

DOI:

https://doi.org/10.18052/www.scipress.com/IJPPE.1.46

Citation:

L. Yusuf et al., "Hepatoprotective Effect of Methanolic Leave Extracts of V. album on Paracetamol-Induced Laboratory Animals", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 1, pp. 46-54, 2015

Online since:

December 2015

Authors:

L. Yusuf, M.K. Oladunmoye, A.O. Ogundare

Keywords:

Hepatoprotective, Hepatotoxicity, Paracetamol, Photomicrograms, Viscum album

Export:

RIS, BibTeX, Text

Distribution:

Open Access

This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

Baek, N. L., Kim, Y. S., Kyung, J. S. and Par, K. H. (1996). Isolation of anti-hepatotoxic agent from roots of Astragalus membranaceous. Korean J Pharmacognosy, 27: 111-6.

Carleton, H. (2007). Carleton's Histological technique. The 4th ed, London, Oxford University, pp.23-27.

Ekhaise, F. O., Ofoezie, V. G. and Enobakhare, D. A. (2010). Antibacterial Properties and Preliminary Phytochemical Analysis of Methanolic Extract of Mistletoe (Tapinanthus bangwensis). Bayero Journal of Pure and Applied Sciences, 3(2): 65-68.

Eno, A. E., Owo, O. I., Itam, E. H. and Konya, R. S. (2004). Blood pressure depression by the V. album in Renal and DOCA-induced hypertension in rats. Phytother. Res. 14: 234-239.

Evans, J. (2005). Mistletoe: Good for more than free kisses. Journal of American Botanical Council, 68: 50 - 59.

Griggs, P. (1991). Mistletoe, myth, magic and medicine. The Biochemist, 13: 3-4.

Jendrassik, L. and Grof, P. (1938). A colorimetry method for determination or serum bilirubin. Biochemistry, 1: 297-81.

Kafaru, E. (1993). Herbal remedies, The Guardian, Thursday June 3, 1993, p.24.

Mehta, R. S., Shankar, M. B., Geetha, M and Saliyu, A. K. (1999). Hepatoprotective activity of Trianthema portulacastrum. Indian Drugs 36: 241-4.

Obatomi, D.K., Aina, V. O. and Temple, V. J. (1996). Effect of African Mistletoe on blood pressure in spontaneously hypertensive rats. International Journal of Pharmacognosy, 34(2): 124-127.

Oyetayo, V. O. and Osho, B. (2004). Assessment of properties of strain of Lactobacillus & Plantarum isolated from fermentry corn slurry (Ogi), Journal of food Agricutlrue and environment, 2(1): 132-134.

Pandit, S., Sur, T. K., Jana, U., Debnath, P. K. and Bhattacharyya, D. (2004). Prevention of carbon tetrachloride-induced hepatotoxicity in rats by Adhatoda vasica leaves, Indian Journal of Pharmacology, 36: 312-133.

Reitmam, S. Frnakel, S. (1957). A colorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic acid transaminases. American Journal of Clininal Pathology, 1: 56-63.

Roy, A. V. (1970). Enzymes in clinical chemistry. Journal of Clinical Chemistry, 16: 431-9.

Setty, R. S. Q. and Ueresh, K. (2007). Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats. Fitoterapia, 78: 451-4.

Tran, Q. L., Adnyana, I. K., Tezuka, Y., Nagaoka, T., Tran, Q. K. and Kadota, S. (2001). Triterpene saponins from Vietnamese ginseng (Panax vietnamensis) and their hepatoprotective activity. J Nat Prod. 64: 456-61.

Ukwueze, S. E. (2008). An evaluation of the Antibacterial Activities of Leaf Extracts from Loranthus micranthus L, Parasitic on Persea americana. Scientia Africana, 7(1): 51-55.

Vijyan, P., Prahant, H. C., Dhanaraj, S. A., Badami, S. and Suresh, B. (2003). Hepatoprotective effect of total alkaloid fraction of Solanum pseudocapsicum leaves. Pharmaceutical Biology, 41: 443-8.

Xiong, X., Chen, W., Cui, J., Yi, S., Zhang, Z. and Li, K. (2003). Effects of ursolic acid on liver protection and bile secretion. Zong Yao Cai, 26: 578-81.

Yusuf, L., Oladunmoye, M. K and Ogundare, A. O. (2013a). In-vivo Antibacterial Activities of Mistletoe (Viscum album) Leaves Extract Growing on Cocoa Tree in Akure North Nigeria. European Journal of Biothecnology and Bioscience, 1(1): 37-42.

Yusuf L, Oladunmoye M. K, Ogundare A. O, Akinyosoye F. A, Hassan G. F, a nd Momoh A.O. (2013b). Comparative antibacterial studies of mistletoes growing on two different host plants in Akure North, Nigeria. International Journal of Medicine and Medical Sciences ISSN: 21670404 Vol. 2 (5).

Yusuf, L., Oladunmoye, M. K., Ogundare, A. O., Mohmo, A. O. and Daudu O. A. Y. (2014).

Yusuf L. (2015).

Show More Hide

Cited By:

This article has no citations.