Hepatoprotective Effect of Methanolic Leave Extracts of V. album on Paracetamol-Induced Laboratory Animals

Yusuf, L.; Oladunmoye, M.K.; Ogundare, A.O.

doi:10.18052/www.scipress.com/IJPPE.1.46

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Hepatoprotective Effect of Methanolic Leave Extracts of V. album on Paracetamol-Induced Laboratory Animals

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Abstract:

Hepatoprotective assay was carried out on laboratory animals in which paracetamol (oral dose,2 g/kg /body weight) was used to induce hepatotoxicity. The animals were orogastrically fed with the Viscum album (growing on cocoa and cola host trees) methanolic leave extracts. The activities of serum enzyme biomarkers showed no significant difference (P< 0.05) for V. album growing on cocoa (1000-5000mg/kg) but there were corresponding significant increase in the serum enzymes (P< 0.05) for V. album growing on cola at 4000 and 5000 mg/kg doses. Similarly, the photomicrograms of the animals’ vital organs (liver, stomach, small intestine and kidneys) studied revealed that V. album extract growing on cocoa was more hepatoprotective efficacious than that growing on cola tree on all the biochemical parameters that were screened for when compared with sylimarin (a standard heptoprotective drug).

Info:

Periodical:

International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 1)

Pages:

46-54

DOI:

https://doi.org/10.18052/www.scipress.com/IJPPE.1.46

Citation:

L. Yusuf et al., "Hepatoprotective Effect of Methanolic Leave Extracts of V. album on Paracetamol-Induced Laboratory Animals", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 1, pp. 46-54, 2015

Online since:

December 2015

Authors:

L. Yusuf, M.K. Oladunmoye, A.O. Ogundare

Keywords:

Hepatoprotective, Hepatotoxicity, Paracetamol, Photomicrograms, Viscum album

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Open Access

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Creative Commons Attribution 4.0 International License

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Yusuf, L., Oladunmoye, M. K., Ogundare, A. O., Mohmo, A. O. and Daudu O. A. Y. (2014).

Yusuf L. (2015).

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[1] A. Szurpnicka, A. Kowalczuk, A. Szterk, "Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action", Archives of Pharmacal Research, 2020

DOI: https://doi.org/10.1007/s12272-020-01247-w